Tbio | Splicing factor 3A subunit 2 |
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8520 | 3.1e-07 |
atypical teratoid / rhabdoid tumor | 5112 | 8.9e-07 |
malignant mesothelioma | 3232 | 2.5e-05 |
psoriasis | 6694 | 3.5e-05 |
medulloblastoma, large-cell | 6241 | 5.3e-05 |
glioblastoma | 5792 | 5.3e-05 |
group 4 medulloblastoma | 1855 | 8.4e-04 |
primitive neuroectodermal tumor | 3035 | 1.2e-03 |
astrocytoma | 1146 | 5.5e-03 |
Gaucher disease type 1 | 180 | 1.9e-02 |
Disease | log2 FC | p |
---|---|---|
astrocytoma | 1.200 | 5.5e-03 |
atypical teratoid / rhabdoid tumor | 1.600 | 8.9e-07 |
Gaucher disease type 1 | 1.300 | 1.9e-02 |
glioblastoma | 1.600 | 5.3e-05 |
group 4 medulloblastoma | 1.200 | 8.4e-04 |
malignant mesothelioma | 1.200 | 2.5e-05 |
medulloblastoma, large-cell | 1.900 | 5.3e-05 |
ovarian cancer | 1.600 | 3.1e-07 |
primitive neuroectodermal tumor | 1.100 | 1.2e-03 |
psoriasis | -1.100 | 3.5e-05 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG |
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYL 1 - 70 AHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDSEMGQQSLLFQIDYPE 71 - 140 IAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFLQF 141 - 210 HFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQL 211 - 280 PPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGV 281 - 350 HPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPG 351 - 420 VHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN 421 - 464 //