Tbio SESN3 Sestrin-3

Protein Summary

Description

May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). This gene encodes a member of the sestrin family of stress-induced proteins. The encoded protein reduces the levels of intracellular reactive oxygen species induced by activated Ras downstream of RAC-alpha serine/threonine-protein kinase (Akt) and FoxO transcription factor. The protein is required for normal regulation of blood glucose, insulin resistance and plays a role in lipid storage in obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

Uniprot Accession IDs

• P58005
• B7Z7P9
• Q96AD1

Gene Name

• SESN3

Ensembl ID

• ENST00000278499
• ENSP00000278499
• ENSG00000149212
• ENST00000416495
• ENSP00000407008
• ENST00000536441
• ENSP00000441927

Symbol

• SEST3
• SEST3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
virus perturbation	0.88
transcription factor binding site profile	0.83
histone modification site profile	0.75
transcription factor	0.74

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Peroxidase / Sestrin-3

DTO Classes

Protein / Enzyme / Oxidoreductase / Peroxidase / Sestrin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.41   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 190   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.41   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0