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Tbio SERTA domain-containing protein 1

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

 Comments

Property Summary

NCBI Gene PubMed Count 26
PubMed Score 20.89
PubTator Score 17.32

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Colonic Neoplasms 142 0.0 0.0
Disease Target Count
Mood Disorders 184

Expression

  Differential Expression (8)

Disease log2 FC p
group 3 medulloblastoma -1.300 1.2e-02
invasive ductal carcinoma -1.192 1.4e-02
medulloblastoma, large-cell -1.200 4.3e-03
non-small cell lung cancer -1.677 2.2e-18
ovarian cancer 1.200 6.2e-04
pancreatic cancer 1.900 7.6e-04
primary pancreatic ductal adenocarcinoma 1.774 4.3e-04
tuberculosis -1.100 8.6e-03

Synonym

Accession Q9UHV2 Q9BUE7
Symbols SEI1
TRIP-Br1

Gene

SERTAD1

PANTHER Protein Class (1)

  Ortholog (10)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG

 UniProt Keyword (6)

 GO Component (2)

 GO Process (4)

 Compartment GO Term (2)

 MGI Phenotype (2)

 HCA RNA Cell Line (56)

See all...

Gene RIF (14)

AA Sequence 

MLSKGLKRKREEEEEKEPLAVDSWWLDPGHTAVAQAPPAVASSSLFDLSVLKLHHSLQQSEPDLRHLVLV      1 - 70
VNTLRRIQASMAPAAALPPVPSPPAAPSVADNLLASSDAALSASMASLLEDLSHIEGLSQAPQPLADEGP     71 - 140
PGRSIGGAAPSLGALDLLGPATGCLLDDGLEGLFEDIDTSMYDNELWAPASEGLKPGPEDGPGKEEAPEL    141 - 210
DEAELDYLMDVLVGTQALERPPGPGR                                                211 - 236
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Text Mined References (27)

PMID Year Title