Tbio SERTAD1 SERTA domain-containing protein 1

Protein Summary

Description

Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F1/TFDP1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of CDKN2A/p16INK4A.

Uniprot Accession IDs

• Q9UHV2
• Q9BUE7

Gene Name

• SERTAD1

Ensembl ID

• ENST00000357949
• ENSP00000350633
• ENSG00000197019

Symbol

• SEI1
• TRIPBR1
• SEI1
• TRIPBR1
• TRIP-Br1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
viral protein	1
virus	1
transcription factor binding site profile	0.89
cell type or tissue	0.65
transcription factor	0.61

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Serta Domain-containing Protein 1

DTO Classes

Protein / Transcription Factor / Serta Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.91   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.91   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0