Tbio SERINC3 Serine incorporator 3

Protein Summary

Description

Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734).

Uniprot Accession IDs

• Q13530
• B4DUE9
• O43717
• Q9BR33

Gene Name

• SERINC3

Ensembl ID

• ENST00000255175
• ENSP00000255175
• ENSG00000132824
• ENST00000342374
• ENSP00000340243

Symbol

• DIFF33
• TDE1
• TDE
• TDE1
• AIGP1
• TMS-1
• DIFF33
• SBBI99

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
transcription factor perturbation	1
virus perturbation	0.99
disease perturbation	0.98
cell type or tissue	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.18   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 165   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.18   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0