Tbio SEPT14 Septin-14

Protein Summary

Description

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions (Peterson et al., 2007 [PubMed 17922164]).[supplied by OMIM, Jul 2008]

Uniprot Accession IDs

• Q6ZU15
• A6NCC2
• B4DXD6

Gene Name

• SEPT14

Ensembl ID

• ENST00000388975
• ENSP00000373627
• ENSG00000154997

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
interacting protein	0.71
microRNA	0.59
cell type or tissue	0.52
tissue	0.48

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-14

Protein / Cytoskeletal Protein / Septin-14

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Septin-14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.44   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 85   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.44   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0