Property Summary

NCBI Gene PubMed Count 43
PubMed Score 68.59
PubTator Score 26.94

Knowledge Summary


No data available


  Disease (1)

Disease Target Count Z-score Confidence
Waterhouse-Friderichsen syndrome 11 3.745 1.9


Protein-protein Interaction (6)

Gene RIF (23)

26511642 High SENP3 expression is associated with stomach neoplasms.
25288641 Evidence show that mTOR-mediated phosphorylation of SENP3 facilitates the interaction with NPM1, thereby promoting nucleolar targeting.
25216525 SENP3, which is increased in gastric cancer cells, potentiates the transcriptional activity of FOXC2 through de-SUMOylation, in favor of the induction of specific mesenchymal gene expression in gastric cancer metastasis.
24930734 SENP3 is associated with MLL1/MLL2 complexes and catalyzes deSUMOylation of RbBP5.
23867815 HIV-1 gp120-treated vaginal epithelial cells show upregulation of SUMO1/sentrin/SMT3 specific peptidase 3 (SENP3) expression as compared to untreated control
23524851 In a novel adaptive pathway to extreme cell stress, dynamic changes in SENP3 stability and regulation of Drp1 SUMOylation are crucial determinants of cell fate.
23467634 ROS induced SENP3 redistribution from the nucleoli to the nucleoplasm.
22684029 The shift of HIF-1 transactivation by reactive oxidative species is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.
21316347 These results suggest that SMT3IP1 is a new regulator of the p53-Mdm2 pathway.
20924358 Hsp90/SENP3 association protects SENP3 from CHIP-mediated ubiquitination and subsequent degradation, but this effect of Hsp90 requires the presence of CHIP.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20406964 Observational study of gene-disease association. (HuGE Navigator)
20337593 Results demonstrate that SENP1 is the most efficient SUMO protease acting on Elk-1, and that SENP3 has little effect on Elk-1. SENP2 has an intermediate effect, but its ability to activate Elk-1 is independent from its SUMO-deconjugating activity.
20181954 SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress.
19913121 Observational study of gene-disease association. (HuGE Navigator)
19773279 Observational study of gene-disease association. (HuGE Navigator)
19680224 SENP3 is a redox sensor that regulates HIF-1 transcriptional activity under oxidative stress through the de-SUMOylation of p300
19423540 Observational study of gene-disease association. (HuGE Navigator)
19015314 Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
18946085 Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway.
18639523 SMT3IP1 desumoylates nucleophosmin and might controls its physiological functions at both the nucleolus and other subcellular compartments.
18259216 These results define SENP3 as an essential factor for ribosome biogenesis and suggest that deconjugation of SUMO2 from NPM1 by SENP3 is critically involved in 28S rRNA maturation.

AA Sequence

RQIYKELCHCKLTV                                                            561 - 574

Text Mined References (49)

PMID Year Title
26511642 2016 SENP3 regulates the global protein turnover and the Sp1 level via antagonizing SUMO2/3-targeted ubiquitination and degradation.
25406032 2014 Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.
25288641 2014 mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3.
25216525 2014 De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells.
24930734 2014 The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.
23524851 2013 SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.
23467634 2013 Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23118916 2012 Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population.
22872859 2012 Five friends of methylated chromatin target of protein-arginine-methyltransferase[prmt]-1 (chtop), a complex linking arginine methylation to desumoylation.
22684029 2012 The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress.
21326211 2011 The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex.
21316347 2011 The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation.
20924358 2010 Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20438785 2010 Polymorphisms in innate immunity genes and risk of childhood leukemia.
20406964 2010 Risk of meningioma and common variation in genes related to innate immunity.
20337593 2010 SENP1 participates in the dynamic regulation of Elk-1 SUMOylation.
20181954 2010 SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19773279 2009 Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19680224 2009 SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation.
19423540 2009 Common variation in genes related to innate immunity and risk of adult glioma.
19015314 2008 Nucleolar protein B23/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases.
18946085 2009 RanBP2 and SENP3 function in a mitotic SUMO2/3 conjugation-deconjugation cycle on Borealin.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18639523 2008 SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin.
18259216 2008 The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16738315 2006 The SUMO-specific protease SENP5 is required for cell division.
16608850 2006 Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.
16565220 2006 Phosphoproteome analysis of the human mitotic spindle.
16381901 2006 The LIFEdb database in 2006.
15960975 2005 Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
15743823 2005 Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors.
15635413 2005 Nucleolar proteome dynamics.
15632193 2005 SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
15489336 2004 From ORFeome to biology: a functional genomics pipeline.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15231748 2004 Functional proteomics mapping of a human signaling pathway.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11256614 2000 Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
11230166 2001 Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
11076863 2000 DNA cloning using in vitro site-specific recombination.
11029585 2000 A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized in the nucleolus at interphase.
10806345 2000 Ubiquitin-like proteins: new wines in new bottles.