Property Summary

NCBI Gene PubMed Count 50
PubMed Score 87.67
PubTator Score 57.96

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Expression

  Differential Expression (6)

Disease log2 FC p
esophageal adenocarcinoma -1.200 1.9e-02
glioblastoma -1.100 9.4e-04
medulloblastoma, large-cell 1.200 2.5e-02
lung cancer 2.200 5.2e-05
interstitial cystitis -1.200 2.6e-03
adult high grade glioma -1.200 1.2e-04

 GO Component (1)

Gene RIF (35)

PMID Text
26784191 A new SEMA3F transcript is expressed in all breast cell lines and breast cancer biopsies, and is translated into a new semaphorin 3F isoform.
26722466 SEMA3F was downregulated in colorectal cancer tissues as compared to matched adjacent non-tumor tissues
26156437 SEMA3F-NRP2 interactions inhibit intracellular PI-3K activity, mTORC2-dependent signaling, RhoA activity and cytoskeletal stress fiber formation.
26086095 Infantile hemangioma-derived stem cells and endothelial cells are inhibited by SEMA3E and SEMA3F.
25952650 SEMA3F may represent an antilymphangiogenic metastasis suppressor gene widely lost during cancer progression, hence serving as a prognostic biomarker and an attractive target for therapeutic intervention to halt metastasis.
25866254 SEMA3F functions as a suppressor of colorectal cancer metastasis by down-regulating the ASCL2-CXCR4 signaling axis.
25529012 Our findings demonstrate the ability of SEMA3F to inhibit the stemness of human CRC cells by suppressing Rac1 activation, which suggests a novel therapeutic approach for colorectal cancer
25068647 Data indicate that semaphorin 3F (SEMA3F) and its receptor neuropilin-2 (NRP2) are expressed in the thymus.
24079887 Data suggest that SEMA3F C-terminal domain exhibits high-affinity binding of neuropilin-1 (NRP1; thus inhibiting binding of vascular endothelial growth factor A to NRP1); this interaction may be involved in anti-angiogenic activity of SEMA3F.
23603393 A functional role for Semaphorin 3F in the outer retina where it acts as a vasorepulsive cue to maintain physiologic avascularity.
22431917 we found that merlin regulated expression of SEMA3F through Rho GTPase family member Rac1
22350413 showed that transcription of SEMA3F is directly regulated by RORalpha
22093159 This study demonstrated a marked loss of noradrenergic and sensory nerve fibers in polyp mucosa, which was associated with a strong increase of semaphorin 3F and 3A.
21610314 It was concluded that hypoxia regulates VEGF and SE MA3F activities through transcriptional repression of their common receptor NRP2, providing a novel mechanism by which hypoxia induces tumor angiogenesis, growth and metastasis.
21349996 Endogenous SEMA3F acts as a suppressor of the growth and metastasis of human colorectal cancer cells.
20388805 Metastatic tumor cells overexpress c-myc, leading to upregulation of Id2 expression; the aberrantly elevated amount of Id2 represses SEMA3F expression and, as a consequence, enhances the ability of tumor cells to migrate and invade.
20198315 Observational study of gene-disease association. (HuGE Navigator)
20198310 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
20124444 semaphorin-3B and semaphorin-3F have roles in ovarian cancer
20036365 SEMA3F, CLEC16A, LAMA3, and PCSK2 variants have roles in myocardial infarction in Japanese individuals
19851296 Observational study of gene-disease association. (HuGE Navigator)
19790074 Soluble neuropilin-2Fc did not inhibit repulsion but increased the repellent effect of semaphorin 3F.
19683737 These data indicate that polymorphisms in SEMA3F are associated with prostate cancer risk and poor prognosis in Hispanic and nonHispanic white men
19683737 Observational study of gene-disease association. (HuGE Navigator)
19657188 Semaphorin3F reverses Multicellular resistance by regulating alpha(v)beta3
19177200 SEMA3F loss was associated with changes in cell signaling: increased phospho-AKT in normoxia and hypoxia-induced factor 1alpha protein. Exogenous addition of SEMA3F could modulate ZEB-1-induced angiogenesis in a chorioallantoic membrane assay.
18818766 Sema3F inhibits tumor development from MDA-MB-435 and MDA-MB-231 and but not MCF-7 or MDA-MB-68 cancer cells. It inhibits tumor angiogenesis in all of the formed tumors. The inhibition is correlated with the expression of neuropilins of the tumors cells.
18660502 ABL2/ARG is a novel mediator of SEMA3F-induced RhoA inactivation and collapsing activity.
18476556 Transient SEMA-3F gene transfection may inhibit the proliferation of Tca8113 cells.
17693432 Semaphorin 3F mRNA forms a G quartet-containing structure, which is recognized with high affinity and specificity by the RGG box domain of the fragile X mental retardation protein.
17569671 combinations of sema3A and sema3F may be able to inhibit tumor angiogenesis more effectively than single semaphorins.
17308083 Results suggest that p53 negatively regulates tumor vessel formation and cell growth via the SEMA3F-NRP2 pathway.
15967098 SEMA3F suppresses lung neoplasm progression in an experimental model
15520858 SEMA3F is a potent metastasis inhibitor that targets both tumor and stromal cells
12659673 SEMA3F and VEGF have antagonistic actions affecting motility in primary tumor cell

AA Sequence

MLVAGLLLWASLLTGAWPSFPTQDHLPATPRVRLSFKELKATGTAHFFNFLLNTTDYRILLKDEDHDRMY      1 - 70
VGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRTHLYVCGTGAYNP     71 - 140
MCTYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTA    141 - 210
SALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFFFR    211 - 280
ERSAEAPQSPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDVFVQQTQDV    281 - 350
RNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMPFSGKMPYPRPGTCPGGTFTPS    351 - 420
MKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVDQVDAADGRYEVLFLGTDRGTV    421 - 490
QKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCL    491 - 560
ARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLECQPRS    561 - 630
PQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLYSCTATENNFKHVVTRVQLHVLGRD    631 - 700
AVHAALFPPLSMSAPPPPGAGPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQ    701 - 770
DQKKPRNRRHHPPDT                                                           771 - 785
//

Text Mined References (51)

PMID Year Title
26784191 2016 Alternative Splicing in Adhesion- and Motility-Related Genes in Breast Cancer.
26722466 2015 Semaphorin-3F functions as a tumor suppressor in colorectal cancer due to regulation by DNA methylation.
26156437 2015 Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo.
26086095 2015 Infantile hemangioma-derived stem cells and endothelial cells are inhibited by class 3 semaphorins.
25952650 2015 Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma.
25866254 2015 SEMA3F prevents metastasis of colorectal cancer by PI3K-AKT-dependent down-regulation of the ASCL2-CXCR4 axis.
25529012 2015 Semaphorin-3F suppresses the stemness of colorectal cancer cells by inactivating Rac1.
25068647 2014 Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors.
24079887 2013 Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F.
23603393 2013 Semaphorin 3F forms an anti-angiogenic barrier in outer retina.
22431917 2012 Merlin/NF2 regulates angiogenesis in schwannomas through a Rac1/semaphorin 3F-dependent mechanism.
22350413 2012 ROR? suppresses breast tumor invasion by inducing SEMA3F expression.
22093159 2012 Loss of sensory and noradrenergic innervation in benign colorectal adenomatous polyps--a putative role of semaphorins 3F and 3A.
21610314 Hypoxia induces tumor and endothelial cell migration in a semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor neuropilin 2.
21349996 2011 Endogenous axon guiding chemorepulsant semaphorin-3F inhibits the growth and metastasis of colorectal carcinoma.
20388805 2010 Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F.
20198315 2010 Association of genetic variants with hemorrhagic stroke in Japanese individuals.
20198310 2010 Association of genetic variants with myocardial infarction in Japanese individuals with different lipid profiles.
20124444 2010 Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer.
20036365 2010 Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals.
19851296 2010 Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals.
19790074 2009 Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber repulsion and arthritis.
19683737 2009 Semaphorin 3B and 3F single nucleotide polymorphisms are associated with prostate cancer risk and poor prognosis.
19657188 2009 Semaphorin3F down-regulates the expression of integrin alpha(v)beta3 and sensitizes multicellular tumor spheroids to chemotherapy via the neuropilin-2 receptor in vitro.
19177200 2009 ZEB-1, a repressor of the semaphorin 3F tumor suppressor gene in lung cancer cells.
18818766 2008 Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells.
18660502 2008 ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells.
18476556 2007 [Effect of human semaphorin-3F gene transient transfection on the proliferation of tongue carcinoma cells].
17693432 2007 Interactions of the G quartet forming semaphorin 3F RNA with the RGG box domain of the fragile X protein family.
17569671 2007 Semaphorin-3A and semaphorin-3F work together to repel endothelial cells and to inhibit their survival by induction of apoptosis.
17308083 2007 Possible role of semaphorin 3F, a candidate tumor suppressor gene at 3p21.3, in p53-regulated tumor angiogenesis suppression.
16641997 2006 The DNA sequence, annotation and analysis of human chromosome 3.
15967098 2005 Selective suppression of in vivo tumorigenicity by semaphorin SEMA3F in lung cancer cells.
15862967 2005 Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin.
15814794 2005 Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance.
15520858 2004 Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12845630 2003 Expression of VEGF, semaphorin SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumours, and cell lines.
12659673 Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10702410 2000 Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration.
10095013 1999 Distribution of semaphorin IV in adult human brain.
9883722 1998 Semaphorin-neuropilin interactions underlying sympathetic axon responses to class III semaphorins.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8786119 1996 Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer.
8649831 1996 Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.
8633026 1996 Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns.
8402908 1993 Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones.
8269517 1993 The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules.
7637782 1995 Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33.
7566098 1995 Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.