Protein Summary
Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. The protein encoded by this gene belongs to the class-3 semaphorin/collapsin family, whose members function in growth cone guidance during neuronal development. This family member inhibits axonal extension and has been shown to act as a tumor suppressor by inducing apoptosis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
- ENST00000433753
- ENSP00000485281
- ENSG00000012171
- ENST00000616701
- ENSP00000484146
- ENST00000618865
- ENSP00000481957
- SEMA5
- SEMAA
- SemA
- SEMA5
- SEMAA
- semaV
- LUCA-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
transcription factor perturbation | 0.74 | ||
transcription factor | 0.73 | ||
PubMedID | 0.66 | ||
cellular component | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 186.04 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 186.04 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0