Property Summary

NCBI Gene PubMed Count 165
PubMed Score 587.50
PubTator Score 650.00

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (16)

Disease log2 FC p
malignant mesothelioma -1.600 8.7e-06
cutaneous lupus erythematosus 1.700 3.3e-03
osteosarcoma -2.356 6.9e-04
medulloblastoma, large-cell -1.100 2.1e-04
non-small cell lung cancer -1.704 1.8e-18
intraductal papillary-mucinous adenoma (... 1.600 1.9e-03
intraductal papillary-mucinous neoplasm ... 2.100 1.3e-02
lung cancer -2.000 8.7e-06
interstitial cystitis 1.600 3.1e-03
group 3 medulloblastoma -1.100 6.1e-03
pilocytic astrocytoma 1.300 2.8e-06
lung adenocarcinoma -1.398 1.1e-07
invasive ductal carcinoma 1.521 2.1e-06
lung carcinoma -2.900 1.1e-33
ulcerative colitis 1.500 5.5e-05
ovarian cancer 1.400 2.7e-03

Protein-protein Interaction (1)

Gene RIF (148)

PMID Text
26975045 PSGL-1 is a novel receptor for S. pneumoniae that contributes to protection against invasive pneumococcal disease.
26539491 This study provides a better understanding of the biology of P-selectin and PSGL-1 and their roles in dissemination and resensitization of Multiple myeloma treatment.
26124272 E-selectin interactions with glycoprotein ligands (CD44/hematopoietic cell E-/L-selectin ligand and PSGL-1) mediate the initial capturing of cells out of flow.
26115234 The solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive.
25445472 CD162 staining and the staining degree, with the other standard immunohistochemical stains, were shown to be beneficial in the diagnosis of multiple myeloma disease.
25428141 Report influence of SELPLG variation on leukocyte-platelet interactions in cardiovascular disease.
25425738 Taken together, these results show that beta-adducin is a pivotal lipid raft-associated protein in PSGL-1-mediated neutrophil rolling on P-selectin.
25405250 expression of P-selectin and P-selectin glycoprotein ligand-1, forming an auto-augmented loop of porcine aortic endothelial cells and platelet activation
25320329 Host membrane protein PSGL-1, CD43, and CD44 association with assembling HIV-1 Gag is driven by polybasic sequences present in the cytoplasmic tails of the membrane proteins and in Gag.
25320329 HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162)
25275127 HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162)
25135296 lymphocyte trafficking into the CNS under VLA-4 blockade can occur by using the alternative adhesion molecules, PSGL-1 and MCAM, the latter representing an exclusive pathway for TH17 cells to migrate over the blood-brain barrier
24997419 SCARB2 and PSGL-1 in human gastrointestinal tract, lung, and brain tissues correlated with the distribution of pathological changes seen in EV71 infection.
24840181 Staphylococcal SElX and SSL6 proteins bind cell surface receptors PSGL-1 and CD47, respectively.
24606340 P-selectin glycoprotein ligand-1 and L-selectin have roles in neutrophil recruitment and activate human endothelial colony-forming cells at the site of vessel injury
24583418 Up-regulation of PSGL-1 on CD14++CD16+ monocytes may play a crucial role in plaque rupture and thrombus formation.
24312591 ligation of PSGL-1 on HL-60 cells activates beta2 integrin, for which lipid raft integrity and Syk activation are responsible
24244398 These findings suggest one molecular mechanism by which bromelain may exert its anti-inflammatory effects is via selective cleavage of PSGL-1 to reduce P-selectin-mediated neutrophil recruitment
24127491 The PSGL-1-L-selectin complex-induced signaling effects on neutrophil slow rolling and recruitment in vivo demonstrate the functional importance of this pathway.
24122451 Phosphoinositide 3-kinase (PI3K) is required for PSGL-1-induced beta1 integrin clustering which ultimately regulates beta1 integrin-mediated Jurkat cell adhesion to fibronectin.
24055812 Specific phosphorylations on 130 and 153 tyrosine residues of p85-bound Rho-GDP dissociation inhibitor-2 are pivotal for P-selectin glycoprotein ligand-1-induced beta1 integrin-mediated lymphocyte adhesion to vascular cell adhesion molecule-1.
23935488 Data suggest that PSGL1 on leukocytes is binding site for VP1 (a capsid protein) in Enterovirus 71; conserved lysine residues on virus surface are responsible for interaction with sulfated tyrosine residues in PSGL1 N-terminus.
23812215 Expression of CD11b and CD162 on monocytes has a temperature-dependent regulation, with decreased expression during hypothermia.
23760234 A receptor-dominated endocytosis of enterovirus 71 infection was observed: PSGL-1 initiates caveola-dependent endocytosis and hSCARB2 activates clathrin-dependent endocytosis.
23750651 Psoriasis patients' tonsils have a higher frequency of skin-homing CLA [cutaneous lymphocyte-associated antigen] positive T cells, correlating significantly with their frequency of blood CLA+ T cells.
23601501 In conclusion, authors report PSGL-1 as a novel target for pneumococcal ZmpC and show that ZmpC inhibits neutrophil extravasation during pneumococcal pneumonia.
23536680 HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162)
23302872 These results indicated that SCARB2 is capable of viral binding, viral internalization, and viral uncoating and that the low infection efficiency of L-PSGL1 cells is due to the inability of PSGL1 to induce viral uncoating.
23192782 PSGL-1 has Janus-faced functions, being both adhesive and anti-adhesive.
22947939 effect of mutation on binding affinity to P- and L-selectin
22830021 HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162)
22535539 The aim of the study was to investigate the degree of platelet activation in NSCLC and the roles of PSGL-1 in the activation of platelets.
22366582 E- and P-selectins play a role in spontaneous metastasis formation both into bone marrow and lungs.
22311979 PSGL-1 EBS plays a critical role in recruiting leukocytes on selectins and in activating the MAPK pathway, whereas it is dispensable to phosphorylate Syk and to lead to alpha(L)beta(2)-dependent leukocyte slow rolling.
22307784 There is significant association between PSGL-1 Met62Ile polymorphism and advanced carotid atherosclerosis with stenosis in female patients from the Serbian population.
22229154 ADAM8 is both associated with PSGL-1 through the ezrin-radixin-moesin actin-binding proteins and able to cause the proteolytic cleavage of this adhesion receptor.
22096244 Data show the contribution of P-selectin glycoprotein ligand-1 (PSGL-1) to the regulation of growth, dissemination, and drug resistance in multiple myeloma (MM) cells in the context of the bone marrow microenvironment.
22021370 Studies indicate that PSGL-1, CD44, and ESL-1 on mature leukocytes are physiologic glycoprotein ligands for endothelial P-selectin and E-selectin.
21880775 Coxsackievirus A24 variant bound better to mouse L929 cells overexpressing human P-selectin glycoprotein ligand-1 (PSGL-1) than to mock-transfected cells, suggesting that PSGL-1 is a candidate receptor for the virus.
21864485 PSGL-1 microparticles show a characteristic course during alloSCT and their possible association with relapse/progress requires further evaluation of the PSGL-1/P-selectin interaction in leukemias and lymphomas
21816455 Exceedingly high PMA in aortic stenosis are independent of SELPLG polymorphisms, and largely of the hemodynamic compromise caused by the stenotic valve.
21768350 Data show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a targets a broad range of human leukocyte glycoproteins including CD43, CD44, CD45, CD93, CD162 and the surface-attached chemokine fractalkine.
21484243 Levels of P-selectin and L-selectin were decreased in AD and lowest in AD patients with highest cognitive decline. Our findings suggest that these molecules may induce alterations of endothelial regulation and influence neurodegenerative processes of AD
21292497 IL-6 induces neutrophilia and reduces CD162 expression on neutrophils in inflammation
21144558 Healthy volunteers were genotyped and the adhesion of neutrophils expressing the PSGL-1 isoforms A/A, A/B and B/B were studied under static and physiologic flow conditions.
21079683 Tyrosine sulfation of the amino terminus of PSGL-1 is associated with enterovirus 71 infection.
21060818 HIV-1 Vpu downregulates the cell surface expression of selectin P ligand (SELPLG, CD162)
21044367 Observational study of gene-disease association. (HuGE Navigator)
20943886 The results suggest that an adaptive mutation, along with a PSGL-1-binding phenotype, may facilitate efficient PSGL-1-dependent replication of enterovirus 71 strains in L-PSGL-1 cells.
20705591 Results suggested that Syk plays a key role in signal transduction downstream of PSGL-1 in endothelial progenitor cells.
20690162 There is a strong expression of both SELPLG and coronin-1C in the majority of primary effusion lymphomas, irrespective of their gene dosage. SELPLG is critical for cell migration and chemotaxis, while CORO1C regulates actin-dependent processes.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20586826 Observational study of gene-disease association. (HuGE Navigator)
20558823 Deficiency of Psgl-1 is associated with reduced IL-1 receptor-mediated adhesive properties of the endothelium.
20445017 Human neutrophil rolling on E- or P-selectin induces the extended alpha(L)beta(2) integrin conformation through signaling triggered by PSGL-1 engagement.
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20406964 Observational study of gene-disease association. (HuGE Navigator)
20376705 The present study demonstrated no evidence of association between individual SELP or PSGL-1 single nucleotide polymorphisms or haplotypes with incident coronary heart disease.
20376705 Observational study of gene-disease association. (HuGE Navigator)
20051472 The adhesion mediated by the P-selectin P-selectin glycoprotein ligand-1 (PSGL-1) couple is stronger for shorter PSGL-1 variants.
19913879 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19875629 PSGL-1 may contribute to T-cell interaction with the inflamed blood brain barrier, and may be a therapeutic taarget in brain multiple sclerosis.
19696154 Multiple sclerosis is associated with an expanding pool of PSGL-1 positive CD4+ T lymphocytes able to transmigrate the BBB endothelium in vitro and possibly contributing to brain pathology.
19665434 Activation of memory CLA(+) CD4(+) T cells results in increased PSGL-1 expression and consequently, increased binding to P-selectin, suggesting a more diverse tissue trafficking capacity.
19628338 cutaneous lymphocyte-associated antigen expression might be an indicator of poor prognosis in non-nasal NK-cell lymphomas with nodal presentation
19543284 a role for PSGL-1-positive leukocytes in cell tropism and pathogenesis during the course of foot and mouth disease and other EV71-mediated diseases.
19542463 Follicular dendritic cells can efficiently activate HIV-1 replication in latently infected monocytic cells via an intercellular communication network mediated by the P-selectin/P-selectin glycoprotein ligand 1 (PSGL-1) interaction.
19423540 Observational study of gene-disease association. (HuGE Navigator)
19404397 Flotillin-1 and -2 associate with PSGL-1 in resting and in stimulated neutrophils are importantly involved in neutrophil uropod formation and/or stabilization
19395438 Specific SELP and SELPLG polymorphisms were associated with cell surface measures of SELP and SELPLG in both whites and African Americans in the ARIC Carotid MRI Study
19395438 Observational study of gene-disease association. (HuGE Navigator)
19353220 This study shows that higher neutrophil PSGL-1 expression on admission may imply a higher risk for END and that monocyte Mac-1 expression on admission reflects the severity of ischemic stroke on admission.
19262138 P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent, but GPCR-independent mechanism.
19074885 Observational study of gene-disease association. (HuGE Navigator)
18773738 HECA-452 could be of prognostic relevance in the early stage of mycosis fungoides
18713749 the role of PSLG1 decamers is to extend PSGL-1 N terminus far above the cell surface to support and stabilize leukocyte rolling on L- or P-selectin
18519846 PSGL-1 level was also higher on human CD14+CD16- monocytes than on CD14-CD16+ monocytes.
18509085 cooperation of the alpha(M)beta(2)/GPIbalpha and to PSGL-1/P-selectin systems regulates the prothrombotic properties of PMN-derived microparticles and MP-induced platelet activation
18497306 Our data suggest that in the absence of overt activation, PSGL-1 (P selectin ligand 1-P-selectin-dependent platelet binding to monocytes represents a normal physiological process with little impact on the potential of monocytes to cause vascular injury
18485118 These data fervently hint that specific recognition of the PSGL-1 N-terminus is crucial for optimal Anaplasma phagocytophilum AnkA delivery.
18452987 Results suggest that the generation of C5a induced by hemodialysis membranes is responsible for the clustered redistribution of PSGL-1 in neutrophils leading to the increase in the platelet-neutrophil microaggregate formation.
18451333 Report complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis.
18363812 P-selectin-PSGL-1-induces TF and IL8 expression through Lyn phosphorylation, and part of the inhibitory effect of IL10 depends on reduced phosphorylation
18250165 a lectin domain residue in L-selectin has a role in binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x
18182036 Observational study of gene-disease association. (HuGE Navigator)
17947642 regulation of O-glycosylation controls sLe(x) expression, and also suggest that O-glycans may have a function in dendritic cells migration
17910894 These findings suggest that 1,25D(3) can selectively downregulate CLA expression without influencing lymphocyte migration patterns to other tissues.
17890399 A new method for determining receptor-ligand association/dissociation events across the interface of two surfaces (two-dimensional binding) by monitoring abrupt decrease/resumption in thermal fluctuations of a biomembrane force probe.
17827388 Observational study of gene-disease association. (HuGE Navigator)
17597069 ADAM28s promotes PSGL-1/P-selectin-mediated leukocyte rolling adhesion to endothelial cells and subsequent infiltration into tissue spaces through interaction with PSGL-1
17545190 Observational study of gene-disease association. (HuGE Navigator)
17545190 It is suggested that the VNTR polymorphism of PSGL-1 is a significant determinant of thrombotic predisposition in patients with APS.
17510705 activation of EphB4 enhances proangiogenic capacity through induction of PSGL-1 expression and adhesion to E selectin and P selectin
17420019 Observational study of gene-disease association. (HuGE Navigator)
17420019 Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes may have roles in coronary heart disease and ischemic stroke
17372146 The association of PSGL-1 with lipid microdomains is essential for its redistribution induced by IL-8 stimulation and that the redistribution modulates neutrophil functions mediated by interactions with P-selectin.
17346310 These data demonstrate a role for Anaplasma phagocytophilum-mediated ROCK1 phosphorylation in infection induced by PSGL-1 and mediated by Syk.
17322099 ECs express functional PSGL-1 which mediates tethering and firm adhesion of monocytes and platelets to inflamed endothelium.
17221329 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
17221329 No significant association was found between PSGL-1 VNTR polymorphisms and in-stent restenosis. However, in patients with a family history of early CAD presence of PSGL-1 AB genotype might increase the risk of in-stent restenosis.
17181632 More than 50% of circulating CD4+CD25(high) regulatory T cells from both patients as well as healthy controls expressed cutaneous lymphocyte-associated antigen.
16633357 rPSGL-Ig delays the aggregation process and increases the anti-aggregatory potency of GPIIb-IIIa antagonist
16547281 98% of CLA(+) effector memory T cells are resident in normal skin under resting conditions
16501095 Plasmacytoid dendritic cells are particularly potent inducers of cutaneous lymphocyte-associated antigen on HSV-reactive memeory CD4 T cells
16269612 CD43 is a T-cell E-selectin ligand distinct from PSGL-1 which expands the role of CD43 in the regulation of T-cell trafficking.
16257118 Observational study of gene-disease association. (HuGE Navigator)
16100264 biophysical analysis of PSGL-1/P-selectin neutrophil adhesion
16039046 Observational study of gene-disease association. (HuGE Navigator)
16039046 In conclusion, the C allele of the VNTR polymorphism in PSGL-1 is likely to be associated with PP-MS.
16024226 CLA is expressed in circulating mononuclear cells of patients with psoriasis
15926890 A differential functional impact of N-glycosylation on C2GnT-1 and FucT-VII and disclose that a strongly reduced FucT-VII activity retains the ability to fucosylate PSGL-1 on the core2-based binding site(s) for the three selectins.
15925831 immune response to alpha-streptococci may enhance expression on tonsillar T-cells in pustulosis palmaris et plantaris
15843584 Induced expression of cutaneous lymphocyte antigen on helper T cells determined a striking increase of rolling efficiency in inflamed brain venules.
15522894 PG-M/versican binds to P-selectin glycoprotein ligand-1 and has a role in mediating leukocyte aggregation
15497463 Observational study of gene-disease association. (HuGE Navigator)
15488708 CLA and E-selectin are bound by T cells and have roles in skin inflammation [cutaneous lymphocyte-associated antigen, also called BE-2]
15466853 PSGL-1 interacts with CCL27 (CTACK/ILC/ESkine), a skin-associated chemokine that attracts skin-homing T lymphocytes
15459589 Observational study of gene-disease association. (HuGE Navigator)
15386532 Observational study of genotype prevalence. (HuGE Navigator)
15217824 The interaction of PSGL-1 with P-selectin (CD62P) mediates tethering, rolling, and weak adhesion of leukocytes
15187162 binding of E-selectin to PMNs in suspension also elicited coclustering of L-selectin and PSGL-1 that was signaled via mitogen-activated protein kinase.
15059608 platelet P-selectin and microparticle PSGL-1 have roles in thrombus formation [review]
15026421 core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 have roles in rolling on P-selectin
15001428 PSGL-1 and VLA-4 play an important role for leukocyte recruitment during intestinal inflammation. Therapeutic strategies designed to disrupt interactions mediated by PSGL-1 and/or VLA-4 may prove beneficial in treatment of chronic colitis.
14678816 platelet-monocyte complex formation is mostly dependent on PSGL-1
14641238 Observational study of gene-disease association. (HuGE Navigator)
14615387 PSGL-1, by mediating monocyte-platelet interactions, plays a major role in secondary monocyte tethering.
14592840 PSGL1 is not essential for E-selection promotion of growth inhibition and apoptosis of human and murine hematopoietic progenitor cells
14507929 determination that PSGL-1 is an additional substrate for BACE1
12879153 Observational study of gene-disease association. (HuGE Navigator)
12879153 results demonstrate that the PSGL-1 variable number of tandem repeat polymorphism is not a genetic risk factor for coronary heart disease
12874338 Anaplasma phagocytophilum infected neutrophils showed reduced expression of P-selectin glycoprotein ligand 1 (PSGL-1, CD162) and L-selectin (CD62L)
12736689 atomic force microscopy and flow-chamber experiments show that increasing force first prolonged and then shortened the lifetimes of P-selectin complexes with P-selectin glycoprotein ligand-1
12736247 L-selectin binds with high affinity to the N-terminal region of PSGL-1 through cooperative interactions with three sulfated tyrosine residues and an appropriately positioned C2-O-sLex O-glycan.
12595306 Anti-P-selectin glycoprotein ligand-1 (PSGL-1) antibodies dramatically block the recruitment of CD8+ cells in brain vessels of patients with multiple sclerosis
12529243 Stimulation of eosinophils with eotaxin-2 converts PSGL-1-P-selectin-dependent stationary adhesion to CD18-mediated shear-resistant stable attachment. Blocking eosinophil-platelet interactions may combat thrombotic disorders in hypereosinophilia.
12393521 Inhibitors of glycosylation alter HECA-452 expression on human cutaneous lymphocyte-associated antigen-positive T-cells and prevent T-cell tethering and rolling on selectins under shear stress.
12387735 PSGL-1 engagement induces tyrosine phosphorylation of Syk and SRE-dependent transcriptional activity.
12377939 increased PSGL-1 expression on granulocytes from allergic-asthmatic subjects resulted in increased leukocyte recruitment on P-selectin under flow conditions
12354382 The epitope recognized by the M-DC8 MAb is 6-sulfo LacNAc, a novel carbohydrate modification of the P selectin glycoprotein ligand 1 (PSGL-1)
12223514 Binding of two anti-human (KPL1 and PL1) and two anti-mouse (4RA10 and 2PH1) PSGL-1 mAbs to synthetic peptides of N-terminus of human and mouse PSGL-1 was found to be independent of tyrosine sulfation.
12189248 Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for herpes simplex virus type 2(cutaneous lymphocyte-associated antigen)
12036880 Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin.
11961238 G-CSF down regulates PSGL-1 expression on the surface of neutrophils in humans
11929779 Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1, E-selectin for adhesive interactions with human vascular endothelium under flow conditions
11916843 Comparison of PSGL-1 microbead and neutrophil rolling: microvillus elongation stabilizes P-selectin bond clusters
11843835 Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)

AA Sequence

MPLQLLLLLILLGPGNSLQLWDTWADEAEKALGPLLARDRRQATEYEYLDYDFLPETEPPEMLRNSTDTT      1 - 70
PLTGPGTPESTTVEPAARRSTGLDAGGAVTELTTELANMGNLSTDSAAMEIQTTQPAATEAQTTQPVPTE     71 - 140
AQTTPLAATEAQTTRLTATEAQTTPLAATEAQTTPPAATEAQTTQPTGLEAQTTAPAAMEAQTTAPAAME    141 - 210
AQTTPPAAMEAQTTQTTAMEAQTTAPEATEAQTTQPTATEAQTTPLAAMEALSTEPSATEALSMEPTTKR    211 - 280
GLFIPFSVSSVTHKGIPMAASNLSVNYPVGAPDHISVKQCLLAILILALVATIFFVCTVVLAVRLSRKGH    281 - 350
MYPVRNYSPTEMVCISSLLPDGGEGPSATANGGLSKAKSPGLTPEPREDREGDDLTLHSFLP            351 - 412
//

Text Mined References (172)

PMID Year Title
26975045 2016 PSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease.
26627825 2016 Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes.
26539491 2015 Inhibition of P-Selectin and PSGL-1 Using Humanized Monoclonal Antibodies Increases the Sensitivity of Multiple Myeloma Cells to Bortezomib.
26124272 2015 Quantitative Characterization of E-selectin Interaction with Native CD44 and P-selectin Glycoprotein Ligand-1 (PSGL-1) Using a Real Time Immunoprecipitation-based Binding Assay.
26115234 2015 Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.
25445472 2015 Relationship of P-selectin glycoprotein ligand-1 to prognosis in patients with multiple myeloma.
25428141 2015 Impact of variables of the P-selectin - P-selectin glycoprotein ligand-1 axis on leukocyte-platelet interactions in cardiovascular disease.
25425738 2015 Lipid raft-associated ?-adducin is required for PSGL-1-mediated neutrophil rolling on P-selectin.
25405250 Role of P-selectin and P-selectin glycoprotein ligand-1 interaction in the induction of tissue factor expression on human platelets after incubation with porcine aortic endothelial cells.
25320329 2015 Basic motifs target PSGL-1, CD43, and CD44 to plasma membrane sites where HIV-1 assembles.
25135296 2014 VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells.
25102098 2014 A girl with West syndrome and autistic features harboring a de novo TBL1XR1 mutation.
24997419 2014 Distribution of EV71 receptors SCARB2 and PSGL-1 in human tissues.
24927181 2014 Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
24840181 2014 Staphylococcus aureus proteins SSL6 and SElX interact with neutrophil receptors as identified using secretome phage display.
24606340 2014 Neutrophils recruit and activate human endothelial colony-forming cells at the site of vessel injury via P-selectin glycoprotein ligand-1 and L-selectin.
24583418 2014 Association between P-selectin glycoprotein ligand-1 and pathogenesis in acute coronary syndrome assessed by optical coherence tomography.
24312591 2013 Lipid Raft is required for PSGL-1 ligation induced HL-60 cell adhesion on ICAM-1.
24244398 2013 Bromelain decreases neutrophil interactions with P-selectin, but not E-selectin, in vitro by proteolytic cleavage of P-selectin glycoprotein ligand-1.
24127491 2013 The PSGL-1-L-selectin signaling complex regulates neutrophil adhesion under flow.
24122451 2014 PI3K is involved in ?1 integrin clustering by PSGL-1 and promotes ?1 integrin-mediated Jurkat cell adhesion to fibronectin.
24055812 2013 p85-RhoGDI2, a novel complex, is required for PSGL-1-induced ?1 integrin-mediated lymphocyte adhesion to VCAM-1.
23935488 2013 Enterovirus 71 binding to PSGL-1 on leukocytes: VP1-145 acts as a molecular switch to control receptor interaction.
23812215 Hypothermia inhibits expression of CD11b (MAC-1) and CD162 (PSGL-1) on monocytes during extracorporeal circulation.
23760234 2013 Caveolar endocytosis is required for human PSGL-1-mediated enterovirus 71 infection.
23750651 2013 The association of sore throat and psoriasis might be explained by histologically distinctive tonsils and increased expression of skin-homing molecules by tonsil T cells.
23601501 2013 Pneumococcal immune evasion: ZmpC inhibits neutrophil influx.
23302872 2013 Functional comparison of SCARB2 and PSGL1 as receptors for enterovirus 71.
23192782 2013 Anti-adhesive property of P-selectin glycoprotein ligand-1 (PSGL-1) due to steric hindrance effect.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22947939 2012 Tyrosine replacement of PSGL-1 reduces association kinetics with P- and L-selectin on the cell membrane.
22535539 2012 Activated platelets interact with lung cancer cells through P-selectin glycoprotein ligand-1.
22366582 2012 Selectin-deficiency reduces the number of spontaneous metastases in a xenograft model of human breast cancer.
22311979 2012 Ezrin-radixin-moesin-binding sequence of PSGL-1 glycoprotein regulates leukocyte rolling on selectins and activation of extracellular signal-regulated kinases.
22307784 2012 The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study.
22229154 2011 The metalloprotease ADAM8 is associated with and regulates the function of the adhesion receptor PSGL-1 through ERM proteins.
22096244 2012 P-selectin glycoprotein ligand regulates the interaction of multiple myeloma cells with the bone marrow microenvironment.
22021370 2011 Leukocyte ligands for endothelial selectins: specialized glycoconjugates that mediate rolling and signaling under flow.
21880775 2011 Coxsackievirus A24 variant uses sialic acid-containing O-linked glycoconjugates as cellular receptors on human ocular cells.
21864485 2011 P-selectin glycoprotein ligand-1 positive microparticles in allogeneic stem cell transplantation of hematologic malignancies.
21816455 2012 High levels of platelet-monocyte aggregates after valve replacement for aortic stenosis: relation to soluble P-selectin and P-selectin glycoprotein ligand-1 genes.
21768350 2011 Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.
21696602 2011 Dynamic reorganization of flotillins in chemokine-stimulated human T-lymphocytes.
21484243 2011 Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration.
21292497 2011 IL-6 plays an essential role in neutrophilia under inflammation.
21144558 2011 Phenotypic differences of human neutrophils of carriers of the PSGL-1 A and B-allele in binding to immobilised P-selectin under flow conditions.
21079683 2010 Tyrosine sulfation of the amino terminus of PSGL-1 is critical for enterovirus 71 infection.
21044367 2010 An integrative method for scoring candidate genes from association studies: application to warfarin dosing.
20943886 2011 Adaptive mutations in the genomes of enterovirus 71 strains following infection of mouse cells expressing human P-selectin glycoprotein ligand-1.
20705591 2010 Overexpression of P-selectin glycoprotein ligand-1 enhances adhesive properties of endothelial progenitor cells through Syk activation.
20690162 2010 Primary effusion lymphoma: genomic profiling revealed amplification of SELPLG and CORO1C encoding for proteins important for cell migration.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20586826 2010 The P-selectin gene polymorphism Val168Met: a novel risk marker for the occurrence of primary ventricular fibrillation during acute myocardial infarction.
20585324 2011 Genome-wide association study of conduct disorder symptomatology.
20558823 2010 P-selectin glycoprotein ligand-1 regulates adhesive properties of the endothelium and leukocyte trafficking into adipose tissue.
20445017 2010 Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils.
20438785 2010 Polymorphisms in innate immunity genes and risk of childhood leukemia.
20406964 2010 Risk of meningioma and common variation in genes related to innate immunity.
20376705 2011 Contribution of SELP and PSGL-1 genotypes and haplotypes to the presence of coronary heart disease in Tunisians.
20051472 2010 The adhesion mediated by the P-selectin P-selectin glycoprotein ligand-1 (PSGL-1) couple is stronger for shorter PSGL-1 variants.
19913879 2010 Combined effects of genetic polymorphisms of P-selectin and P-selectin glycoprotein ligand-1 on the binding of platelets to monocytes.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19875629 2009 PSGL-1--the hidden player in T cell trafficking into the brain in multiple sclerosis?
19696154 2009 Peripheral blood CD4+ T lymphocytes from multiple sclerosis patients are characterized by higher PSGL-1 expression and transmigration capacity across a human blood-brain barrier-derived endothelial cell line.
19665434 2009 Cutaneous lymphocyte-associated antigen (CLA) T cells up-regulate P-selectin ligand expression upon their activation.
19628338 2010 NK-cell lymphoma with nodal presentation and expression of cutaneous lymphocyte-associated antigen.
19543284 2009 Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71.
19542463 2009 Follicular dendritic cells activate HIV-1 replication in monocytes/macrophages through a juxtacrine mechanism mediated by P-selectin glycoprotein ligand 1.
19423540 2009 Common variation in genes related to innate immunity and risk of adult glioma.
19404397 2009 Flotillins interact with PSGL-1 in neutrophils and, upon stimulation, rapidly organize into membrane domains subsequently accumulating in the uropod.
19395438 2009 SELP and SELPLG genetic variation is associated with cell surface measures of SELP and SELPLG: the Atherosclerosis Risk in Communities Carotid MRI Study.
19353220 2009 The value of leukocyte adhesion molecules in patients after ischemic stroke.
19262138 P-selectin cross-links PSGL-1 and enhances neutrophil adhesion to fibrinogen and ICAM-1 in a Src kinase-dependent, but GPCR-independent mechanism.
19074885 2008 Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
18773738 2008 Expression of HECA-452 antigen correlates with disease relapse in mycosis fungoides.
18713749 2008 P-selectin glycoprotein ligand-1 decameric repeats regulate selectin-dependent rolling under flow conditions.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18519846 2008 P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice.
18509085 2008 Expression, activation, and function of integrin alphaMbeta2 (Mac-1) on neutrophil-derived microparticles.
18497306 2008 Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status.
18485118 2008 Anaplasma phagocytophilum PSGL-1-independent infection does not require Syk and leads to less efficient AnkA delivery.
18452987 2008 Redistribution of P-selectin ligands on neutrophil cell membranes and the formation of platelet-neutrophil complex induced by hemodialysis membranes.
18451333 2008 Complete downmodulation of P-selectin glycoprotein ligand in monocytes undergoing apoptosis.
18363812 2008 Tissue factor and IL8 production by P-selectin-dependent platelet-monocyte aggregates in whole blood involves phosphorylation of Lyn and is inhibited by IL10.
18250165 2008 Replacing a lectin domain residue in L-selectin enhances binding to P-selectin glycoprotein ligand-1 but not to 6-sulfo-sialyl Lewis x.
18196517 2008 SLIC-1/sorting nexin 20: a novel sorting nexin that directs subcellular distribution of PSGL-1.
18182036 2008 Selectin haplotypes and the risk of venous thrombosis: influence of linkage disequilibrium with the factor V Leiden mutation.
17947642 2007 Sialyl-Lewis(x) on P-selectin glycoprotein ligand-1 is regulated during differentiation and maturation of dendritic cells: a mechanism involving the glycosyltransferases C2GnT1 and ST3Gal I.
17910894 2008 Vitamins A and D are potent inhibitors of cutaneous lymphocyte-associated antigen expression.
17890399 2008 Monitoring receptor-ligand interactions between surfaces by thermal fluctuations.
17827388 2007 Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.
17597069 2007 Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells.
17545190 2007 P-selectin glycoprotein ligand-1 VNTR polymorphisms and risk of thrombosis in the antiphospholipid syndrome.
17510705 2007 PSGL-1-mediated activation of EphB4 increases the proangiogenic potential of endothelial progenitor cells.
17420019 2007 Specific P-selectin and P-selectin glycoprotein ligand-1 genotypes/haplotypes are associated with risk of incident CHD and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) study.
17372146 2007 Redistribution of P-selectin glycoprotein ligand-1 (PSGL-1) in chemokine-treated neutrophils: a role of lipid microdomains.
17346310 2007 Anaplasma phagocytophilum specifically induces tyrosine phosphorylation of ROCK1 during infection.
17322099 2007 P-selectin glycoprotein ligand-1 is expressed on endothelial cells and mediates monocyte adhesion to activated endothelium.
17221329 2007 The association of P-selectin glycoprotein ligand-1 VNTR polymorphisms with coronary stent restenosis.
17181632 2007 Frequency, function and CLA expression of CD4+CD25+FOXP3+ regulatory T cells in bullous pemphigoid.
16633357 2006 Recombinant P-selectin glycoprotein-ligand-1 delays thrombin-induced platelet aggregation: a new role for P-selectin in early aggregation.
16547281 2006 The vast majority of CLA+ T cells are resident in normal skin.
16541075 2006 The finished DNA sequence of human chromosome 12.
16501095 2006 Innate immune responses to herpes simplex virus type 2 influence skin homing molecule expression by memory CD4+ lymphocytes.
16269612 2006 CD43 is a ligand for E-selectin on CLA+ human T cells.
16257118 2006 SELPLG and SELP single-nucleotide polymorphisms in multiple sclerosis.
16100264 2005 Neutrophil-bead collision assay: pharmacologically induced changes in membrane mechanics regulate the PSGL-1/P-selectin adhesion lifetime.
16039046 2005 P-selectin glycoprotein ligand-1 variable number of tandem repeats (VNTR) polymorphism in patients with multiple sclerosis.
16024226 2005 Follow-up analysis of circulating mononuclear cell CLA expression in patients with psoriasis.
15926890 2005 N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding.
15925831 2005 Expression of cutaneous lymphocyte-associated antigen (CLA) in tonsillar T-cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis palmaris et plantaris (PPP).
15843584 2005 Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII.
15522894 2004 PG-M/versican binds to P-selectin glycoprotein ligand-1 and mediates leukocyte aggregation.
15497463 2004 Polymorphisms in the P-selectin (CD62P) and P-selectin glycoprotein ligand-1 (PSGL-1) genes and coronary heart disease.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15488708 2004 In vivo evidence for close association of CLA expression and E-selectin binding by T cells in the inflamed skin.
15466853 2004 Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus.
15459589 2004 Short alleles of P-selectin glycoprotein ligand-1 protect against premature myocardial infarction.
15386532 Turkish population data on the factor XIII Val34Leu,glycoprotein (GP)Ibalpha Kozak and P-selectin glycoprotein ligand 1 (PSGL-1) loci.
15217824 2004 P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils.
15187162 2004 Shear-dependent capping of L-selectin and P-selectin glycoprotein ligand 1 by E-selectin signals activation of high-avidity beta2-integrin on neutrophils.
15059608 2004 Role of platelet P-selectin and microparticle PSGL-1 in thrombus formation.
15026421 2004 Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of P-selectin glycoprotein ligand-1 in rolling on P-selectin.
15001428 2004 Immunoblockade of PSGL-1 attenuates established experimental murine colitis by reduction of leukocyte rolling.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14678816 2003 Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting.
14641238 2003 SELPLG gene polymorphisms in relation to plasma SELPLG levels and coronary artery disease.
14615387 2004 Platelet-monocyte complexes support monocyte adhesion to endothelium by enhancing secondary tethering and cluster formation.
14592840 2004 Adhesion to E-selectin promotes growth inhibition and apoptosis of human and murine hematopoietic progenitor cells independent of PSGL-1.
14507929 2003 The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1.
12879153 2003 The variable number of tandem repeat polymorphism in the P-selectin glycoprotein ligand-1 gene is not associated with coronary heart disease.
12874338 2003 Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin.
12736689 2003 Direct observation of catch bonds involving cell-adhesion molecules.
12736247 2003 Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.
12595306 2003 CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1.
12529243 2003 Exogenous eosinophil activation converts PSGL-1-dependent binding to CD18-dependent stable adhesion to platelets in shear flow.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12403782 2003 Molecular basis of leukocyte rolling on PSGL-1. Predominant role of core-2 O-glycans and of tyrosine sulfate residue 51.
12393521 2003 Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin.
12387735 2002 ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1.
12377939 2002 Increased PSGL-1 expression on granulocytes from allergic-asthmatic subjects results in enhanced leukocyte recruitment under flow conditions.
12354382 2002 6-Sulfo LacNAc, a novel carbohydrate modification of PSGL-1, defines an inflammatory type of human dendritic cells.
12223514 2002 Binding of function-blocking mAbs to mouse and human P-selectin glycoprotein ligand-1 peptides with and without tyrosine sulfation.
12189248 2002 Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific for a skin-tropic virus.
12115638 2002 A juxta-membrane amino acid sequence of P-selectin glycoprotein ligand-1 is involved in moesin binding and ezrin/radixin/moesin-directed targeting at the trailing edge of migrating lymphocytes.
12036880 2002 Attachment of the PSGL-1 cytoplasmic domain to the actin cytoskeleton is essential for leukocyte rolling on P-selectin.
11929779 2002 Human mast cell progenitors use alpha4-integrin, VCAM-1, and PSGL-1 E-selectin for adhesive interactions with human vascular endothelium under flow conditions.
11843835 2001 Polymorphisms of P-selectin glycoprotein ligand-1 are associated with neutrophil-platelet adhesion and with ischaemic cerebrovascular disease.
11566773 2001 Tyrosine sulfation enhances but is not required for PSGL-1 rolling adhesion on P-selectin.
11520793 2001 Regulation of P-selectin binding to the neutrophil P-selectin counter-receptor P-selectin glycoprotein ligand-1 by neutrophil elastase and cathepsin G.
11081633 2000 Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.
10834846 2000 Intracellular parasitism by the human granulocytic ehrlichiosis bacterium through the P-selectin ligand, PSGL-1.
10807781 2000 Interleukin-13 induces PSGL-1/P-selectin-dependent adhesion of eosinophils, but not neutrophils, to human umbilical vein endothelial cells under flow.
10770806 2000 P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo.
10725346 2000 Modification of P-selectin glycoprotein ligand-1 with a natural killer cell-restricted sulfated lactosamine creates an alternate ligand for L-selectin.
10713099 2000 Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin.
10599889 1999 Expression of homing receptors and related molecules on human mast cells and basophils: a comparative analysis using multi-color flow cytometry and toluidine blue/immunofluorescence staining techniques.
9804815 1998 Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat.
9486531 1997 The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives.
9414280 1998 A novel P-selectin glycoprotein ligand-1 monoclonal antibody recognizes an epitope within the tyrosine sulfate motif of human PSGL-1 and blocks recognition of both P- and L-selectin.
9353122 1997 Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells.
9128259 1997 Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin.
8839831 1996 P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation.
8702529 1996 Structures of the O-glycans on P-selectin glycoprotein ligand-1 from HL-60 cells.
8621728 1996 Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.
7585950 1995 PSGL-1 recognition of P-selectin is controlled by a tyrosine sulfation consensus at the PSGL-1 amino terminus.
7585949 1995 A sulfated peptide segment at the amino terminus of PSGL-1 is critical for P-selectin binding.
7559387 1995 Tyrosine sulfation of P-selectin glycoprotein ligand-1 is required for high affinity binding to P-selectin.
7541799 1995 Genomic organization and chromosomal localization of the gene encoding human P-selectin glycoprotein ligand.
7521878 1994 The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.
7505206 1993 Expression cloning of a functional glycoprotein ligand for P-selectin.