SEC11A
Signal peptidase complex catalytic subunit SEC11A
Protein Summary
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. This gene encodes a member of the peptidase S26B family. The encoded protein is an 18kDa subunit of the signal peptidase complex and has been linked to cell migration and invasion, gastric cancer and lymph node metastasis. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Dec 2012]
- ENST00000268220
- ENSP00000268220
- ENSG00000140612
- ENST00000455959
- ENSP00000413121
- ENST00000558134
- ENSP00000452697
- ENST00000560266
- ENSP00000452684
- SEC11L1
- SPC18
- SPCS4A
- SPC18
- SPCS4A
- SEC11L1
- sid2895
- 1810012E07Rik
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
virus perturbation | 1 | ||
kinase perturbation | 0.95 | ||
protein domain | 0.85 | ||
transcription factor binding site profile | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.18 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 165 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 23.18 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 165 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0