SCYL3
Protein-associating with the carboxyl-terminal domain of ezrin
Protein Summary
May play a role in regulating cell adhesion/migration complexes in migrating cells. This gene encodes a protein with a kinase domain and four HEAT repeats. The encoded protein interacts with the C-terminal domain of ezrin, an ERM protein, and may play a role in cell adhesion and migration. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
- ENST00000367770
- ENSP00000356744
- ENSG00000000457
- ENST00000367771
- ENSP00000356745
- ENST00000367772
- ENSP00000356746
- PACE1
- PACE1
- PACE-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.86 | ||
transcription factor binding site profile | 0.86 | ||
virus perturbation | 0.85 | ||
kinase perturbation | 0.76 | ||
histone modification site profile | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.39 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 221 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.39 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 221 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0