Tbio SCYL1 N-terminal kinase-like protein

Protein Summary

Description

Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). Has no detectable kinase activity in vitro (PubMed:18556652). Isoform 6 acts as transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q96KG9
• A6NJF1
• Q96G50
• Q96KG8
• Q96KH1
• Q9HAW5
• Q9HBL3
• Q9NR53

Gene Name

• SCYL1

Ensembl ID

• ENST00000270176
• ENSP00000270176
• ENSG00000142186
• ENST00000420247
• ENSP00000408192
• ENST00000533862
• ENSP00000437254

Symbol

• CVAK90
• GKLP
• NTKL
• TAPK
• TEIF
• TRAP
• GKLP
• NKTL
• NTKL
• P105
• TAPK
• TEIF
• TRAP
• HT019
• SCAR21

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
interacting protein	0.89
cellular component	0.8
histone modification site profile	0.8
kinase perturbation	0.71

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Other Group / Scy1 Family / N-terminal Kinase-like Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 147   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.12   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0