Tclin SCN11A Sodium channel protein type 11 subunit alpha

Protein Summary

Description

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is highly expressed in nociceptive neurons of dorsal root ganglia and trigeminal ganglia. It mediates brain-derived neurotrophic factor-evoked membrane depolarization and is a major effector of peripheral inflammatory pain hypersensitivity. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy type VII and familial episodic pain syndrome-3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2017]

Uniprot Accession IDs

• Q9UI33
• A6NN05
• C9JD48
• C9JR31
• Q68K15
• Q8NDX3
• Q9UHE0
• Q9UHM0

Gene Name

• SCN11A

Ensembl ID

• ENST00000302328
• ENSP00000307599
• ENSG00000168356
• ENST00000444237
• ENSP00000408028
• ENST00000456224
• ENSP00000416757

Symbol

• SCN12A
• SNS2
• NaN
• PN5
• FEPS3
• HSAN7
• SNS-2
• NAV1.9
• SCN12A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.76
gene perturbation	0.74
protein domain	0.73
cell type or tissue	0.71
small molecule perturbation	0.49

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Sodium Channel / Sodium Channel Protein Type 11 Subunit Alpha

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Calcium Channel / Sodium Channel Protein Type 11 Subunit Alpha

Protein / Transporter / Ion Channel / Sodium Channel / Voltage-gated Sodium Channel / Sodium Channel Protein Type 11 Subunit Alpha

Protein / Transporter / Ion Channel / Calcium Channel / Voltage-gated Calcium Channel / Sodium Channel Protein Type 11 Subunit Alpha

DTO Classes

Protein / Ion Channel / Sodium Channel Family / Nav1.9/scn11a Subfamily / Sodium Channel Protein Type 11 Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.94   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 987.94   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 8