Tbio SCGB1A1 Uteroglobin

Protein Summary

Description

Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2. This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• P11684
• B2R5F2
• Q6FHH3
• Q9UCM2
• Q9UCM4

Gene Name

• SCGB1A1

Ensembl ID

• ENST00000278282
• ENSP00000278282
• ENSG00000149021

Symbol

• CC10
• CCSP
• UGB
• UGB
• UP1
• CC10
• CC16
• CCSP
• UP-1
• CCPBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.96
biological process	0.85
metabolite	0.78
biological term	0.76
cellular component	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Uteroglobin

DTO Classes

Protein / Signaling / Cytokine / Uteroglobin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1240.19   (req: < 5)

Gene RIFs: 127   (req: <= 3)

Antibodies: 344   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1240.19   (req: >= 5)

Gene RIFs: 127   (req: > 3)

Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0