| Tbio | Histone deacetylase complex subunit SAP18 |
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 1.2e-22 |
| psoriasis | 6694 | 1.6e-07 |
| lung adenocarcinoma | 2716 | 7.3e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.1e-04 |
| medulloblastoma, large-cell | 6241 | 2.0e-04 |
| ovarian cancer | 8520 | 2.7e-04 |
| adult high grade glioma | 3801 | 6.6e-04 |
| Multiple myeloma | 1332 | 8.9e-04 |
| osteosarcoma | 7950 | 1.7e-03 |
| dermatomyositis | 966 | 1.8e-03 |
| lung cancer | 4740 | 2.0e-03 |
| glioblastoma | 5792 | 8.6e-03 |
| invasive ductal carcinoma | 2951 | 1.7e-02 |
| non primary Sjogren syndrome sicca | 891 | 4.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pallister-Hall syndrome | 10 | 4.083 | 2.0 |
| Rubinstein-Taybi syndrome | 10 | 3.446 | 1.7 |
| Newborn respiratory distress syndrome | 10 | 3.297 | 1.6 |
| Coronary thrombosis | 3 | 3.028 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.200 | 6.6e-04 |
| atypical teratoid / rhabdoid tumor | -1.100 | 1.1e-04 |
| dermatomyositis | 1.400 | 1.8e-03 |
| glioblastoma | -1.100 | 8.6e-03 |
| invasive ductal carcinoma | -1.200 | 1.7e-02 |
| lung adenocarcinoma | -1.100 | 7.3e-07 |
| lung cancer | -1.200 | 2.0e-03 |
| medulloblastoma, large-cell | -1.500 | 2.0e-04 |
| Multiple myeloma | 1.155 | 8.9e-04 |
| non primary Sjogren syndrome sicca | 1.100 | 4.3e-02 |
| non-small cell lung cancer | -1.364 | 1.2e-22 |
| osteosarcoma | -1.753 | 1.7e-03 |
| ovarian cancer | -1.700 | 2.7e-04 |
| psoriasis | -1.300 | 1.6e-07 |
