| Tbio | SAM domain-containing protein SAMSN-1 |
Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity).
SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]
SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.9e-23 |
| periodontitis | 293 | 1.7e-19 |
| non-small cell lung cancer | 2890 | 2.7e-08 |
| lung carcinoma | 2843 | 6.0e-07 |
| malignant mesothelioma | 3232 | 6.5e-06 |
| Astrocytoma, Pilocytic | 3081 | 1.1e-05 |
| tuberculosis | 2010 | 8.9e-05 |
| ulcerative colitis | 1819 | 1.2e-04 |
| cutaneous lupus erythematosus | 1057 | 6.9e-04 |
| primary Sjogren syndrome | 735 | 9.8e-04 |
| lung cancer | 4740 | 1.1e-03 |
| glioblastoma | 5792 | 2.5e-03 |
| interstitial cystitis | 2312 | 2.6e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.8e-03 |
| ovarian cancer | 8520 | 5.4e-03 |
| invasive ductal carcinoma | 2951 | 6.8e-03 |
| posterior fossa group A ependymoma | 468 | 7.8e-03 |
| Atopic dermatitis | 952 | 1.1e-02 |
| Rheumatoid arthritis | 1191 | 1.2e-02 |
| group 4 medulloblastoma | 1855 | 1.3e-02 |
| adult high grade glioma | 3801 | 1.7e-02 |
| medulloblastoma, large-cell | 6241 | 2.9e-02 |
| aldosterone-producing adenoma | 665 | 3.3e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 4.3e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 1.7e-02 |
| aldosterone-producing adenoma | -1.173 | 3.3e-02 |
| Astrocytoma, Pilocytic | 2.000 | 1.1e-05 |
| Atopic dermatitis | 1.500 | 1.1e-02 |
| cutaneous lupus erythematosus | 3.000 | 6.9e-04 |
| glioblastoma | 1.100 | 2.5e-03 |
| group 4 medulloblastoma | -1.400 | 1.3e-02 |
| interstitial cystitis | 2.000 | 2.6e-03 |
| intraductal papillary-mucinous adenoma (... | -1.600 | 4.3e-02 |
| intraductal papillary-mucinous carcinoma... | -2.200 | 4.8e-03 |
| invasive ductal carcinoma | 1.708 | 6.8e-03 |
| lung cancer | -2.300 | 1.1e-03 |
| lung carcinoma | -1.500 | 6.0e-07 |
| malignant mesothelioma | -1.500 | 6.5e-06 |
| medulloblastoma, large-cell | -1.700 | 2.9e-02 |
| non-small cell lung cancer | -1.135 | 2.7e-08 |
| ovarian cancer | -1.600 | 5.4e-03 |
| periodontitis | 1.300 | 1.7e-19 |
| posterior fossa group A ependymoma | 1.300 | 7.8e-03 |
| primary Sjogren syndrome | 1.500 | 9.8e-04 |
| psoriasis | 1.700 | 1.9e-23 |
| Rheumatoid arthritis | 1.600 | 1.2e-02 |
| tuberculosis | -2.200 | 8.9e-05 |
| ulcerative colitis | 2.200 | 1.2e-04 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MLKRKPSNVSEKEKHQKPKRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGSGEQSKTSNNGGGLGKKM 1 - 70 RAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKVSLKASDSMDSLYSGQSSSSGIT 71 - 140 SCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDSLKIKKGDIIDIICKTPMGMWTGMLNNK 141 - 210 VGNFKFIYVDVISEEEAAPKKIKANRRSNSKKSKTLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESH 211 - 280 LIELNIENPDDRRRLLSAAENFLEEEIIQEQENEPEPLSLSSDISLNKSQLDDCPRDSGCYISSGNSDNG 281 - 350 KEDLESENLSDMVHKIIITEPSD 351 - 373 //
