Tbio SAMSN1 SAM domain-containing protein SAMSN-1

Protein Summary

Description

Negative regulator of B-cell activation. Down-regulates cell proliferation (in vitro). Promotes RAC1-dependent membrane ruffle formation and reorganization of the actin cytoskeleton. Regulates cell spreading and cell polarization. Stimulates HDAC1 activity. Regulates LYN activity by modulating its tyrosine phosphorylation (By similarity). SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9NSI8
• B3KWJ3
• F8WAA1
• Q8NFF7
• Q9C041

Gene Name

• SAMSN1

Ensembl ID

• ENST00000285670
• ENSP00000285670
• ENSG00000155307
• ENST00000400564
• ENSP00000383409
• ENST00000400566
• ENSP00000383411

Symbol

• HACS1
• SLy2
• HACS1
• NASH1
• SASH2
• SH3D6B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.86
protein domain	0.85
kinase perturbation	0.76
transcription factor perturbation	0.74
gene perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.79   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 231   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.79   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0