Tbio SAMD8 Sphingomyelin synthase-related protein 1

Protein Summary

Description

Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.

Uniprot Accession IDs

• Q96LT4
• Q5JSC5
• Q5JSC8
• Q66K52
• SMSr

Gene Name

• SAMD8

Ensembl ID

• ENST00000372687
• ENSP00000361772
• ENSG00000156671
• ENST00000542569
• ENSP00000438042

Symbol

• SMSr
• HEL-177

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.92
microRNA	0.87
transcription factor perturbation	0.8
histone modification site profile	0.78
transcription factor binding site profile	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.46   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.46   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0