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Tchem
RXFP1
Relaxin receptor 1

Protein Summary
Description
Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307765
  • ENSP00000303248
  • ENSG00000171509
  • ENST00000343542
  • ENSP00000345889
  • ENST00000470033
  • ENSP00000420712
  • ENST00000471616
  • ENSP00000434475

Symbol
  • LGR7
  • LGR7
  • RXFPR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
ligand (protein)
0.68
biological term
0.64
cell type or tissue
0.59
cell line
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.77   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.77   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 34
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0