Tdark RUNDC1 RUN domain-containing protein 1

Protein Summary

Description

May play a role as p53/TP53 inhibitor and thus may have oncogenic activity. This gene encodes a protein that contains a RUN (RPIP8, UNC-14 and NESCA) domain and a coiled coil domain. The encoded protein may negatively regulate p53 transcriptional activity. This gene is a potential candidate gene for predisposition to glioma in humans. [provided by RefSeq, May 2017]

Uniprot Accession IDs

• Q96C34
• Q6Y2K8
• Q8IXT9
• Q8N3W1

Gene Name

• RUNDC1

Ensembl ID

• ENST00000361677
• ENSP00000354622
• ENSG00000198863

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.93
virus perturbation	0.79
kinase perturbation	0.66
cell line	0.58
tissue sample	0.58

Protein Classes

PANTHER Classes

Protein / Hydrolase / Run Domain-containing Protein 1

Protein / Enzyme Modulator / G-protein Modulator / Run Domain-containing Protein 1

Protein / ... / Cysteine Protease / Run Domain-containing Protein 1

DTO Classes

Protein / Enzyme / Protease / Cysteine Protease / Run Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 60   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.66   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0