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Tbio Kunitz-type protease inhibitor 2

Inhibitor of HGF activator. Also inhibits plasmin, plasma and tissue kallikrein, and factor XIa.

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

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Property Summary

NCBI Gene PubMed Count 57
PubMed Score 182.35
PubTator Score 101.69

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Pain agnosia 104 4.049 2.0
Diarrhea 253 3.763 1.9
Cancer 2499 3.041 1.5

Expression

  Differential Expression (20)

Disease log2 FC p
adult high grade glioma -1.900 2.7e-05
astrocytic glioma -2.200 2.3e-03
Astrocytoma, Pilocytic -1.900 8.1e-08
breast carcinoma 1.700 4.4e-03
ductal carcinoma in situ 2.800 2.0e-03
ependymoma -2.400 3.9e-03
fibroadenoma 2.300 4.1e-02
glioblastoma -2.100 2.2e-10
group 3 medulloblastoma -2.800 7.8e-06
interstitial cystitis -1.400 5.0e-02
intraductal papillary-mucinous carcinoma... 1.300 7.4e-04
invasive ductal carcinoma 3.100 7.3e-03
lung adenocarcinoma 1.264 1.5e-05
lung cancer 1.100 3.7e-02
medulloblastoma, large-cell -1.800 2.2e-04
oligodendroglioma -2.100 6.4e-03
osteosarcoma -2.401 2.0e-03
ovarian cancer 2.200 2.7e-04
pancreatic ductal adenocarcinoma liver m... 2.320 3.0e-02
primitive neuroectodermal tumor -1.100 3.2e-02

Synonym

Accession O43291 A8K667 B4DLU1 O00271 O14895 Q5TZQ3 Q969E0
Symbols PB
Kop
HAI2
DIAR3
HAI-2

Gene

SPINT2

  Ortholog (10)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid EggNOG

 UniProt Keyword (16)

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 GO Function (2)

 GO Component (4)

 GO Process (9)

 Compartment GO Term (13)

 MGI Phenotype (4)

 GWAS Trait (2)

 HCA RNA Cell Line (56)

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Pathway (5)

Protein-protein Interaction (70)

RNF13   TUBGCP2   LSR   ATP12A   LIN54   TBC1D9B   TBC1D15   ATP2A3   ITPRIPL1   FNDC3A   ZNF696   THAP11   IQCB1   LEMD3   POM121   UBR3   ATP8B2   NFRKB   ZDHHC13   RETSAT   DHRS7   SPTLC2   CCZ1   MARC1   CYP51A1   PRR14   LRIF1   MAP7D3   TYW1   C20orf24   MOSPD2   BAG3   KIF14   EPHX1   TAF6L   NOP9   NUS1   SLC35F5   TEX264   CKAP5   GPN3   UPK3BL2   FNDC3B   VRK2   MZT2B   SLC39A10   ELF2   SLC39A6   C1orf112   USP33   GOLGA5   GTPBP3   DAGLB   VANGL2   DPH1   FRMD5   CHD8   PI4K2B   SLC27A3   ARL6IP6   EGFL7   PKMYT1   HGFAC   LRP10   CNTNAP1   ZDHHC18   SCARF2   TIGD5   LRP12   ASPHD2  

PDB (1)

Gene RIF (42)

AA Sequence 

MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGG      1 - 70
CDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG     71 - 140
PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLI    141 - 210
LFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL                                211 - 252
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Text Mined References (59)

PMID Year Title