Tbio RTN2 Reticulon-2

Protein Summary

Description

This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]

Uniprot Accession IDs

• O75298
• O60509
• Q7RTM6
• Q7RTN1
• Q7RTN2

Gene Name

• RTN2

Ensembl ID

• ENST00000245923
• ENSP00000245923
• ENSG00000125744
• ENST00000344680
• ENSP00000345127
• ENST00000430715
• ENSP00000398178

Symbol

• NSPL1
• NSP2
• NSPL1
• NSPLI
• SPG12

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
small molecule perturbation	0.78
tissue sample	0.69
cellular component	0.67
transcription factor binding site profile	0.63
transcription factor	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.69   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 132   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.69   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0