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Tbio
RRN3
RNA polymerase I-specific transcription initiation factor RRN3

Protein Summary
Description
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000198767
  • ENSP00000198767
  • ENSG00000085721
  • ENST00000327307
  • ENSP00000318484
  • ENST00000564131
  • ENSP00000454238
  • ENST00000616334
  • ENSP00000480743
  • ENSG00000278494
  • ENST00000632541
  • ENSP00000488651
  • ENST00000634151
  • ENSP00000487821

Symbol
  • TIFIA
  • TIFIA
  • A-270G1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
biological process
0.81
kinase
0.81
transcription factor binding site profile
0.81
protein complex
0.76


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.75   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.75   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0