| Tbio | 40S ribosomal protein S5 |
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 6.1e-06 |
| medulloblastoma, large-cell | 6241 | 3.1e-05 |
| ovarian cancer | 8520 | 4.0e-05 |
| medulloblastoma | 720 | 7.7e-05 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.8e-04 |
| lung cancer | 4740 | 1.8e-03 |
| diabetes mellitus | 1728 | 2.2e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 2.3e-03 |
| inflammatory breast cancer | 286 | 4.8e-03 |
| acute myeloid leukemia | 783 | 2.4e-02 |
| mucosa-associated lymphoid tissue lymphoma | 484 | 3.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chromosome 2p16.1-p15 deletion syndrome | 8 | 4.538 | 2.3 |
| Retinitis pigmentosa 14 | 7 | 4.519 | 2.3 |
| Short QT syndrome | 12 | 4.032 | 2.0 |
| Gonorrhea | 13 | 3.082 | 1.5 |
| Long QT syndrome | 39 | 3.052 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 2.000 | 2.4e-02 |
| atypical teratoid / rhabdoid tumor | 1.200 | 6.1e-06 |
| diabetes mellitus | -1.100 | 2.2e-03 |
| inflammatory breast cancer | -1.400 | 4.8e-03 |
| intraductal papillary-mucinous adenoma (... | -1.200 | 2.3e-03 |
| intraductal papillary-mucinous neoplasm ... | -1.800 | 7.8e-04 |
| lung cancer | 1.400 | 1.8e-03 |
| medulloblastoma | 1.300 | 7.7e-05 |
| medulloblastoma, large-cell | 1.700 | 3.1e-05 |
| mucosa-associated lymphoid tissue lympho... | -1.219 | 3.6e-02 |
| ovarian cancer | -1.500 | 4.0e-05 |
