Protein Summary
May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).
- ENST00000325926
- ENSP00000314946
- ENSG00000177519
- REPRIMO
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.79 | ||
gene perturbation | 0.73 | ||
PubMedID | 0.73 | ||
small molecule perturbation | 0.69 | ||
histone modification site profile | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.34 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 76 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 47.34 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 76 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0