Property Summary

NCBI Gene PubMed Count 16
PubMed Score 19.36
PubTator Score 8.66

Knowledge Summary


No data available


  Disease (2)

Disease Target Count P-value
pancreatic ductal adenocarcinoma liver metastasis 1795 7.3e-04
Disease Target Count Z-score Confidence
Retroperitoneal sarcoma 1 4.416 2.2


  Differential Expression (1)

Disease log2 FC p
pancreatic ductal adenocarcinoma liver m... -1.961 7.3e-04


Accession Q9NQG5 Q1WDE7 Q6PKF4
Symbols CREPT



4FLA   4FU3   4HFG   4NAD   4Q94   4Q96  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (7)

26819409 a detailed description of proteins associating with K-H/RPRD1B in higher-order protein complexes is required to further elucidate its role in various cellular processes
25400738 CREPT displays unique immunostaining for retroperitoneal leiomyosarcoma tissue and can be used to supplement other currently available markers.
24997600 RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and coordinate the dephosphorylation of RNAPII phospho-S5 by RPAP2.
24982424 study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling.
24589584 This study reports that K-H functions in RNAPII regulation, and aids in stabilizing interactions between transcription termination factors, localizing Xrn2 to the 3'-end of genes and ultimately suppressing R-loop formation.
24452636 RPRD1B overexpression promotes tumor growth and accelerates cell cycle progression.
22264791 CREPT increases cyclin D1 transcription during tumorigenesis.

AA Sequence


Text Mined References (25)

PMID Year Title
26819409 2016 The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair.
25545209 2014 Characterization of a monoclonal antibody against CREPT, a novel protein highly expressed in tumors.
25400738 2014 CREPT expression correlates with poor prognosis in patients with retroperitoneal leiomyosarcoma.
24997600 2014 RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation.
24982424 2014 CREPT/RPRD1B, a recently identified novel protein highly expressed in tumors, enhances the ?-catenin·TCF4 transcriptional activity in response to Wnt signaling.
24589584 2014 Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair.
24452636 2014 RPRD1B promotes tumor growth by accelerating the cell cycle in endometrial cancer.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22264791 2012 CREPT accelerates tumorigenesis by regulating the transcription of cell-cycle-related genes.
22231121 Control of the RNA polymerase II phosphorylation state in promoter regions by CTD interaction domain-containing proteins RPRD1A and RPRD1B.
22223895 2012 Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-?-acetylation features.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21269460 2011 Initial characterization of the human central proteome.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16189514 2005 Towards a proteome-scale map of the human protein-protein interaction network.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15302935 2004 Large-scale characterization of HeLa cell nuclear phosphoproteins.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11780052 2001 The DNA sequence and comparative analysis of human chromosome 20.