RPGRIP1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1
Protein Summary
May function as scaffolding protein. Required for normal location of RPGR at the connecting cilium of photoreceptor cells. Required for normal disk morphogenesis and disk organization in the outer segment of photoreceptor cells and for survival of photoreceptor cells. This gene encodes a photoreceptor protein that interacts with retinitis pigmentosa GTPase regulator protein and is a key component of cone and rod photoreceptor cells. Mutations in this gene lead to autosomal recessive congenital blindness. [provided by RefSeq, Oct 2008]
- ENST00000382933
- ENSP00000372391
- ENSG00000092200
- ENST00000400017
- ENSP00000382895
- LCA6
- RGI1
- RGRIP
- CORD13
- RPGRIP
- RPGRIP1d
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.77 | ||
virus perturbation | 0.72 | ||
tissue sample | 0.62 | ||
co-expressed gene | 0.57 | ||
cell line | 0.55 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.11 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 88 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 31.11 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 88 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0