| Tdark | Serine/arginine-rich splicing factor 8 |
Involved in pre-mRNA alternative splicing.
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Breast cancer | 3578 | 9.5e-11 |
| osteosarcoma | 7950 | 3.7e-04 |
| adult high grade glioma | 3801 | 1.3e-03 |
| ovarian cancer | 8520 | 2.2e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.2e-03 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.100 | 1.3e-03 |
| atypical teratoid / rhabdoid tumor | -1.300 | 3.2e-03 |
| Breast cancer | -1.300 | 9.5e-11 |
| osteosarcoma | -1.819 | 3.7e-04 |
| ovarian cancer | -1.200 | 2.2e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.118 | 2.7e-02 |
MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFVRFHDRRDAQD 1 - 70 AEAAMDGAELDGRELRVQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRSYGRRSRSPRRRHRSRSRGPS 71 - 140 CSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRYRESRYGGSHYSSSGYSNSRYSRYHSSRSHS 141 - 210 KSGSSTSSRSASTSKSSSARRSKSSSVSRSRSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQM 211 - 280 SS 281 - 282 //
