Protein Summary
Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
- ENST00000184183
- ENSP00000184183
- ENSG00000065371
- ENST00000405845
- ENSP00000385919
- ENST00000459660
- ENSP00000420590
- ENST00000479867
- ENSP00000420567
- ENST00000484329
- ENSP00000419205
- ENST00000495093
- ENSP00000417379
- ENST00000620893
- ENSP00000483603
- ROPN1A
- CT91
- ODF6
- ROPN1A
- RHPNAP1
- ropporin
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 0.64 | ||
cell type or tissue | 0.56 | ||
gene perturbation | 0.56 | ||
cell line | 0.45 | ||
tissue | 0.42 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.24 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 53 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 21.24 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 53 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0