Tdark RNFT1 E3 ubiquitin-protein ligase RNFT1

Protein Summary

Description

E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.

Uniprot Accession IDs

• Q5M7Z0
• Q8N7D0
• Q96IZ9
• Q9Y686

Gene Name

• RNFT1

Ensembl ID

• ENST00000305783
• ENSP00000304670
• ENSG00000189050
• ENST00000482446
• ENSP00000436144

Symbol

• PTD016

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78
transcription factor perturbation	0.68
cell line	0.55
tissue sample	0.54
cellular component	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.63   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.63   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0