Property Summary

NCBI Gene PubMed Count 13
PubMed Score 6.66
PubTator Score 6.78

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (17)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.404 1.8e-02
Multiple myeloma 1.322 1.6e-02
astrocytic glioma -1.100 4.5e-02
osteosarcoma 1.163 4.3e-02
atypical teratoid / rhabdoid tumor -1.800 4.8e-06
glioblastoma -1.800 1.4e-04
medulloblastoma -1.600 2.7e-05
medulloblastoma, large-cell -2.100 7.1e-05
primitive neuroectodermal tumor -1.400 4.2e-04
hereditary spastic paraplegia -1.264 1.0e-02
juvenile dermatomyositis 1.158 4.2e-07
Parkinson's disease -1.300 4.2e-02
Breast cancer 3.200 4.2e-02
adult high grade glioma -1.400 1.5e-02
primary Sjogren syndrome 1.100 3.9e-02
ovarian cancer -1.100 6.8e-03
Gaucher disease type 1 -1.800 3.3e-03

Protein-protein Interaction (3)

Gene RIF (4)

PMID Text
26971355 This study thus suggests that RNF6 overexpression in leukemia is under the direction of PBX1 and that the PBX1/RNF6 axis can be developed as a novel therapeutic target of leukemia.
18368307 Results describe thet cloning and identification of a novel RNF6 transcriptional splice variant, Spg2, in human development.
16204183 Rnf6 controls cellular LIMK1 concentrations and indicate a new function for the ubiquitin/proteasome system in regulating local growth cone actin dynamics
11971979 Functional anaylysis of the mouse homolog

AA Sequence

MNQSRSRSDGGSEETLPQDHNHHENERRWQQERLHREEAYYQFINELNDEDYRLMRDHNLLGTPGEITSE      1 - 70
ELQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRTGNATRSGQNGNQTWRAVSRT     71 - 140
NPNNGEFRFSLEIHVNHENRGFEIHGEDYTDIPLSDSNRDHTANRQQRSTSPVARRTRSQTSVNFNGSSS    141 - 210
NIPRTRLASRGQNPAEGSFSTLGRLRNGIGGAAGIPRANASRTNFSSHTNQSGGSELRQREGQRFGAAHV    211 - 280
WENGARSNVTVRNTNQRLEPIRLRSTSNSRSRSPIQRQSGTVYHNSQRESRPVQQTTRRSVRRRGRTRVF    281 - 350
LEQDRERERRGTAYTPFSNSRLVSRITVEEGEESSRSSTAVRRHPTITLDLQVRRIRPGENRDRDSIANR    351 - 420
TRSRVGLAENTVTIESNSGGFRRTISRLERSGIRTYVSTITVPLRRISENELVEPSSVALRSILRQIMTG    421 - 490
FGELSSLMEADSESELQRNGQHLPDMHSELSNLGTDNNRSQHREGSSQDRQAQGDSTEMHGENETTQPHT    491 - 560
RNSDSRGGRQLRNPNNLVETGTLPILRLAHFFLLNESDDDDRIRGLTKEQIDNLSTRHYEHNSIDSELGK    561 - 630
ICSVCISDYVTGNKLRQLPCMHEFHIHCIDRWLSENCTCPICRQPVLGSNIANNG                   631 - 685
//

Text Mined References (16)

PMID Year Title
26971355 2016 The Ring Finger Protein RNF6 Induces Leukemia Cell Proliferation as a Direct Target of Pre-B-cell Leukemia Homeobox 1.
26871637 2016 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
24509480 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
22159054 2011 A comprehensive genetic association study of Alzheimer disease in African Americans.
19345326 2009 Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination.
18368307 2008 Cloning and identification of a novel RNF6 transcriptional splice variant Spg2 in human development.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16204183 2005 The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
15057823 2004 The DNA sequence and analysis of human chromosome 13.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12154016 2002 Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma.
10331950 1999 Cloning and characterization of RNF6, a novel RING finger gene mapping to 13q12.