| Tbio | E3 ubiquitin-protein ligase RNF180 |
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 1.3e-13 |
| astrocytoma | 1146 | 1.4e-11 |
| Astrocytoma, Pilocytic | 3081 | 9.4e-06 |
| ependymoma | 4679 | 3.4e-05 |
| pituitary cancer | 1972 | 1.0e-04 |
| medulloblastoma, large-cell | 6241 | 1.3e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 5.0e-04 |
| ovarian cancer | 8520 | 1.7e-03 |
| glioblastoma | 5792 | 2.0e-03 |
| ductal carcinoma in situ | 1745 | 2.1e-03 |
| invasive ductal carcinoma | 2951 | 5.7e-03 |
| interstitial cystitis | 2312 | 1.1e-02 |
| adult high grade glioma | 3801 | 1.5e-02 |
| primitive neuroectodermal tumor | 3035 | 1.8e-02 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.3e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.6e-02 |
| oligodendroglioma | 2850 | 3.5e-02 |
| Breast cancer | 3578 | 3.8e-02 |
| group 3 medulloblastoma | 4104 | 4.3e-02 |
| osteosarcoma | 7950 | 4.5e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 1.5e-02 |
| astrocytoma | 1.400 | 1.4e-11 |
| Astrocytoma, Pilocytic | 1.800 | 9.4e-06 |
| atypical teratoid / rhabdoid tumor | -1.800 | 2.3e-02 |
| Breast cancer | 2.000 | 3.8e-02 |
| ductal carcinoma in situ | -1.100 | 2.1e-03 |
| ependymoma | 1.200 | 3.4e-05 |
| glioblastoma | 1.200 | 2.0e-03 |
| group 3 medulloblastoma | -1.200 | 4.3e-02 |
| interstitial cystitis | -1.200 | 1.1e-02 |
| intraductal papillary-mucinous carcinoma... | -2.000 | 5.0e-04 |
| intraductal papillary-mucinous neoplasm ... | -1.600 | 2.6e-02 |
| invasive ductal carcinoma | -1.400 | 5.7e-03 |
| lung adenocarcinoma | -1.500 | 1.3e-13 |
| medulloblastoma, large-cell | -1.800 | 1.3e-04 |
| oligodendroglioma | 2.000 | 3.5e-02 |
| osteosarcoma | -1.228 | 4.5e-02 |
| ovarian cancer | -1.100 | 1.7e-03 |
| pituitary cancer | 1.200 | 1.0e-04 |
| primitive neuroectodermal tumor | 1.300 | 1.8e-02 |
MKRSKELITKNHSQEETSILRCWKCRKCIASSGCFMEYLENQVIKDKDDSVDAQNICHVWHMNVEALPEW 1 - 70 ISCLIQKAQWTVGKLNCPFCGARLGGFNFVSTPKCSCGQLAAVHLSKSRTDYQPTQAGRLMRPSVKYLSH 71 - 140 PRVQSGCDKEALLTGGGSENRNHRLLNMARNNNDPGRLTEALCLEVRPTYFEMKNEKLLSKASEPKYQLF 141 - 210 VPQLVTGRCATRAFHRKSHSLDLNISEKLTLLPTLYEIHSKTTAYSRLNETQPIDLSGLPLQSSKNSYSF 211 - 280 QNPSSFDPSMLLQRFSVAPHETQTQRGGEFQCGLEAASVYSDHTNTNNLTFLMDLPSAGRSMPEASDQEE 281 - 350 HLSPLDFLHSANFSLGSINQRLNKRERSKLKNLRRKQRRRERWLQKQGKYSGVGLLDHMTLNNEMSTDED 351 - 420 NEYAEEKDSYICAVCLDVYFNPYMCYPCHHIFCEPCLRTLAKDNPSSTPCPLCRTIISRVFFQTELNNAT 421 - 490 KTFFTKEYLKIKQSFQKSNSAKWPLPSCRKAFHLFGGFRRHAAPVTRRQFPHGAHRMDYLHFEDDSRGWW 491 - 560 FDMDMVIIYIYSVNWVIGFIVFCFLCYFFFPF 561 - 592 //
