| Tdark | E3 ubiquitin-protein ligase RNF149 |
E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2844 | 2.6e-21 |
| juvenile dermatomyositis | 1189 | 5.2e-11 |
| acute quadriplegic myopathy | 1157 | 3.2e-06 |
| tuberculosis and treatment for 6 months | 686 | 1.7e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 7.5e-04 |
| aldosterone-producing adenoma | 664 | 9.0e-03 |
| ovarian cancer | 8491 | 1.2e-02 |
| primary pancreatic ductal adenocarcinoma | 1271 | 3.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| pancreatic cancer | 2300 | 0.0 | 1.0 |
| Disease | log2 FC | p |
|---|---|---|
| juvenile dermatomyositis | 1.440 | 5.2e-11 |
| acute quadriplegic myopathy | 1.145 | 3.2e-06 |
| primary pancreatic ductal adenocarcinoma | 1.309 | 3.2e-02 |
| tuberculosis and treatment for 6 months | -1.300 | 1.7e-04 |
| intraductal papillary-mucinous neoplasm ... | 1.800 | 7.5e-04 |
| aldosterone-producing adenoma | -1.019 | 9.0e-03 |
| lung carcinoma | -1.400 | 2.6e-21 |
| ovarian cancer | 1.800 | 1.2e-02 |
| pancreatic cancer | 1.200 | 2.8e-02 |
| PMID | Text | |
|---|---|---|
| 22628551 | Data show that RNF149 (RING finger protein 149) interacts with wild-type BRAF. |
MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRFGDSSPK 1 - 70 EGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTFKDKVLVAARRNASAVVLYNE 71 - 140 ERYGNITLPMSHAGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSVVFVAIAFIT 141 - 210 MMIISLAWLIFYYIQRFLYTGSQIGSQSHRKETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKD 211 - 280 IIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPGDVQEMPAPESPPGRDPAANLSLALPD 281 - 350 DDGSDDSSPPSASPAESEPQCDPSFKGDAGENTALLEAGRSDSRHGGPIS 351 - 400 //
| PMID | Year | Title | |
|---|---|---|---|
| 23376485 | 2013 | Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. | |
| 22628551 | 2012 | Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF). | |
| 20686608 | 2010 | Genome-wide association study of pancreatic cancer in Japanese population. | |
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| 18029348 | 2008 | Toward a confocal subcellular atlas of the human proteome. | |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. | |
| 16959974 | 2006 | The consensus coding sequences of human breast and colorectal cancers. | |
| 16381901 | 2006 | The LIFEdb database in 2006. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 15815621 | 2005 | Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | |
| 15489336 | 2004 | From ORFeome to biology: a functional genomics pipeline. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11076863 | 2000 | DNA cloning using in vitro site-specific recombination. |
