| Tdark | E3 ubiquitin-protein ligase RNF149 |
E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 2.6e-21 |
| juvenile dermatomyositis | 1187 | 5.2e-11 |
| acute quadriplegic myopathy | 1158 | 3.2e-06 |
| tuberculosis and treatment for 6 months | 409 | 1.7e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 7.5e-04 |
| ovarian cancer | 8520 | 7.3e-03 |
| aldosterone-producing adenoma | 665 | 9.0e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 3.2e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| pancreatic cancer | 2398 | 0.0 | 0.0278805480578136 |
| Disease | log2 FC | p |
|---|---|---|
| pancreatic cancer | 1.200 | 2.8e-02 |
| acute quadriplegic myopathy | 1.145 | 3.2e-06 |
| aldosterone-producing adenoma | -1.019 | 9.0e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.800 | 7.5e-04 |
| juvenile dermatomyositis | 1.440 | 5.2e-11 |
| lung carcinoma | -1.400 | 2.6e-21 |
| ovarian cancer | -1.100 | 7.3e-03 |
| primary pancreatic ductal adenocarcinoma | 1.309 | 3.2e-02 |
| tuberculosis and treatment for 6 months | -1.300 | 1.7e-04 |
MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRFGDSSPK 1 - 70 EGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTFKDKVLVAARRNASAVVLYNE 71 - 140 ERYGNITLPMSHAGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSVVFVAIAFIT 141 - 210 MMIISLAWLIFYYIQRFLYTGSQIGSQSHRKETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKD 211 - 280 IIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPGDVQEMPAPESPPGRDPAANLSLALPD 281 - 350 DDGSDDSSPPSASPAESEPQCDPSFKGDAGENTALLEAGRSDSRHGGPIS 351 - 400 //
