Tdark RNF133 E3 ubiquitin-protein ligase RNF133

Protein Summary

Description

Has E3 ubiquitin-protein ligase activity. The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene has no intron. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8WVZ7
• A4D0W2
• Q8N7G7

Gene Name

• RNF133

Ensembl ID

• ENST00000340112
• ENSP00000344489
• ENSG00000188050

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.94
cell type or tissue	0.59
cell line	0.5
tissue	0.42
disease	0.41

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 184   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.65   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0