| Tbio | Rho-related GTP-binding protein Rho6 |
Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.
This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]
This gene encodes a protein that belongs to the Rho GTPase family. Members of this family regulate the organization of the actin cytoskeleton in response to extracellular growth factors. A similar protein in rat interacts with a microtubule regulator to control axon extension. [provided by RefSeq, Apr 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 3.0e-08 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.1e-08 |
| glioblastoma | 5792 | 2.3e-06 |
| Astrocytoma, Pilocytic | 3081 | 7.3e-06 |
| medulloblastoma, large-cell | 6241 | 1.9e-05 |
| adult high grade glioma | 3801 | 8.5e-05 |
| lung cancer | 4740 | 9.2e-05 |
| psoriasis | 6694 | 1.2e-04 |
| primitive neuroectodermal tumor | 3035 | 2.0e-03 |
| group 3 medulloblastoma | 4104 | 5.9e-03 |
| astrocytic glioma | 2597 | 7.3e-03 |
| ependymoma | 4679 | 7.5e-03 |
| oligodendroglioma | 2850 | 3.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Alcoholic psychosis | 6 | 4.421 | 2.2 |
| Arts syndrome | 26 | 3.509 | 1.8 |
| REM sleep behavior disorder | 14 | 3.058 | 1.5 |
| Status asthmaticus | 5 | 3.035 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.200 | 8.5e-05 |
| astrocytic glioma | -1.400 | 7.3e-03 |
| Astrocytoma, Pilocytic | -1.700 | 7.3e-06 |
| atypical teratoid / rhabdoid tumor | -2.600 | 5.1e-08 |
| ependymoma | -2.100 | 7.5e-03 |
| glioblastoma | -1.700 | 2.3e-06 |
| group 3 medulloblastoma | -1.900 | 5.9e-03 |
| lung cancer | -3.200 | 9.2e-05 |
| medulloblastoma, large-cell | -3.300 | 1.9e-05 |
| non-small cell lung cancer | -1.854 | 3.0e-08 |
| oligodendroglioma | -1.100 | 3.4e-02 |
| primitive neuroectodermal tumor | -1.700 | 2.0e-03 |
| psoriasis | 1.600 | 1.2e-04 |
