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Tbio Ribonuclease 7

Exhibits a potent RNase activity. Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium.

The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein has broad-spectrum antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

 Comments

Property Summary

NCBI Gene PubMed Count 25
PubMed Score 35.48
PubTator Score 40.03

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
psoriasis 6694 6.2e-16
Atopic dermatitis 952 9.6e-05
spina bifida 1074 4.6e-02
Disease Target Count Z-score Confidence
Pityriasis versicolor 19 3.436 1.7

Expression

  Differential Expression (3)

Disease log2 FC p
psoriasis 1.500 6.2e-16
Atopic dermatitis -1.700 9.6e-05
spina bifida -2.447 4.6e-02

Synonym

Accession Q9H1E1 P80927 P83685 Q546N3 RNase 7
Symbols RAE1

Gene

RNASE7

  Ortholog (2)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (14)

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 GO Function (5)

 GO Component (4)

 GO Process (8)

 Compartment GO Term (9)

 HCA RNA Cell Line (19)

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Pathway (3)

Protein-protein Interaction (1)

RNH1  

PDB (1)

Gene RIF (15)

AA Sequence 

MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNT      1 - 70
FLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKK     71 - 140
DSQQFHLVPVHLDRVL                                                          141 - 156
//

Text Mined References (27)

PMID Year Title