| Tbio | RecQ-mediated genome instability protein 1 |
Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM, Mar 2008]
RMI1 is a component of protein complexes that limit DNA crossover formation via the dissolution of double Holliday junctions (Raynard et al., 2006 [PubMed 16595695]).[supplied by OMIM, Mar 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| breast carcinoma | 1638 | 5.1e-31 |
| non-small cell lung cancer | 2890 | 1.7e-15 |
| malignant mesothelioma | 3232 | 1.3e-06 |
| ductal carcinoma in situ | 1745 | 1.0e-05 |
| Breast cancer | 3578 | 1.2e-05 |
| hepatocellular carcinoma | 547 | 3.9e-05 |
| lung cancer | 4740 | 7.3e-05 |
| primitive neuroectodermal tumor | 3035 | 1.4e-04 |
| posterior fossa group B ependymoma | 416 | 1.8e-04 |
| invasive ductal carcinoma | 2951 | 2.2e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 7.0e-03 |
| group 3 medulloblastoma | 4104 | 1.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bloom syndrome | 29 | 5.848 | 2.9 |
| Fanconi anemia | 56 | 3.056 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.100 | 7.0e-03 |
| Breast cancer | 1.400 | 1.2e-05 |
| breast carcinoma | 1.200 | 5.1e-31 |
| ductal carcinoma in situ | 1.400 | 1.0e-05 |
| group 3 medulloblastoma | 1.400 | 1.2e-02 |
| hepatocellular carcinoma | 1.300 | 3.9e-05 |
| intraductal papillary-mucinous neoplasm ... | 1.300 | 1.6e-02 |
| invasive ductal carcinoma | 1.300 | 2.2e-03 |
| lung cancer | 2.300 | 7.3e-05 |
| malignant mesothelioma | 1.400 | 1.3e-06 |
| non-small cell lung cancer | 1.214 | 1.7e-15 |
| posterior fossa group B ependymoma | 1.100 | 1.8e-04 |
| primitive neuroectodermal tumor | 1.500 | 1.4e-04 |
MNVTSIALRAETWLLAAWHVKVPPMWLEACINWIQEENNNVNLSQAQMNKQVFEQWLLTDLRDLEHPLLP 1 - 70 DGILEIPKGELNGFYALQINSLVDVSQPAYSQIQKLRGKNTTNDLVTAEAQVTPKPWEAKPSRMLMLQLT 71 - 140 DGIVQIQGMEYQPIPILHSDLPPGTKILIYGNISFRLGVLLLKPENVKVLGGEVDALLEEYAQEKVLARL 141 - 210 IGEPDLVVSVIPNNSNENIPRVTDVLDPALGPSDEELLASLDENDELTANNDTSSERCFTTGSSSNTIPT 211 - 280 RQSSFEPEFVISPRPKEEPSNLSIHVMDGELDDFSLEEALLLEETVQKEQMETKELQPLTFNRNADRSIE 281 - 350 RFSHNPNTTNNFSLTCKNGNNNWSEKNVSEQMTNEDKSFGCPSVRDQNRSIFSVHCNVPLAHDFTNKEKN 351 - 420 LETDNKIKQTSSSDSHSLNNKILNREVVNYVQKRNSQISNENDCNLQSCSLRSSENSINLSIAMDLYSPP 421 - 490 FVYLSVLMASKPKEVTTVKVKAFIVTLTGNLSSSGGIWSITAKVSDGTAYLDVDFVDEILTSLIGFSVPE 491 - 560 MKQSKKDPLQYQKFLEGLQKCQRDLIDLCCLMTISFNPSLSKAMVLALQDVNMEHLENLKKRLNK 561 - 625 //
