Tbio RLN2 Prorelaxin H2

Protein Summary

Description

Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. May be involved in remodeling of connective tissues during pregnancy, promoting growth of pubic ligaments and ripening of the cervix. This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P04090
• A0AVM0
• Q99936
• Q9UCX3
• Q9UQJ2

Gene Name

• RLN2

Ensembl ID

• ENST00000381627
• ENSP00000371040
• ENSG00000107014

Symbol

• H2
• RLXH2
• H2-RLX
• bA12D24.1.1
• bA12D24.1.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
biological term	0.64
protein domain	0.58
tissue	0.57
pathway	0.5

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Prorelaxin H2

DTO Classes

Protein / Signaling / Hormone / Prorelaxin H2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.97   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.97   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0