Tbio RITA1 RBPJ-interacting and tubulin-associated protein 1

Protein Summary

Description

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.

Uniprot Accession IDs

• Q96K30
• B3KVZ4
• C9JIN1
• F8VRG5
• Q53GM3
• Q96K25

Gene Name

• RITA1

Ensembl ID

• ENST00000548278
• ENSP00000449841
• ENSG00000139405
• ENST00000549621
• ENSP00000448289
• ENST00000552495
• ENSP00000448680

Symbol

• C12orf52
• RITA
• RITA
• C12orf52

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
histone modification site profile	0.91
cell type or tissue	0.71
transcription factor	0.63
transcription factor binding site profile	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.84   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.84   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0