Tbio RIT2 GTP-binding protein Rit2

Protein Summary

Description

Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q99578
• B2R9L1
• O15295
• Q8TD69
• Q8WVF6
• Q92964

Gene Name

• RIT2

Ensembl ID

• ENST00000326695
• ENSP00000321805
• ENSG00000152214
• ENST00000589109
• ENSP00000467217

Symbol

• RIN
• ROC2
• RIN
• RIBA
• ROC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.93
trait	0.75
cell type or tissue	0.65
phenotype	0.65
gene perturbation	0.63

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtp-binding Protein Rit2

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Gtp-binding Protein Rit2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.19   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 246   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.19   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0