| Tchem | Serine/threonine-protein kinase RIO3 |
Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3 (PubMed:24807708). Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling (PubMed:25865883). Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway (PubMed:19557502). May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA (PubMed:22418843).
This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
This gene was first identified by the similarity of its product to the Aspergillus nidulans SUDD protein. This gene is now recognized as a member of the right open reading frame (RIO) kinase gene family. This gene encodes a serine/threonine kinase that localizes to the cytoplasm and plays a role in the processing of the pre-40 S ribosomal subunit. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 6.9e-08 |
| ependymoma | 4679 | 1.3e-06 |
| medulloblastoma, large-cell | 6241 | 1.2e-04 |
| group 4 medulloblastoma | 1855 | 8.5e-04 |
| hereditary spastic paraplegia | 318 | 2.6e-03 |
| colon cancer | 1478 | 3.9e-03 |
| dermatomyositis | 966 | 4.7e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.3e-02 |
| aldosterone-producing adenoma | 665 | 1.8e-02 |
| Gaucher disease type 1 | 180 | 1.9e-02 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 1.9e-02 |
| spina bifida | 1074 | 3.8e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Diverticulitis | 11 | 4.931 | 2.5 |
| Disease | log2 FC | p |
|---|---|---|
| aldosterone-producing adenoma | -1.138 | 1.8e-02 |
| colon cancer | -1.100 | 3.9e-03 |
| dermatomyositis | -1.200 | 4.7e-03 |
| ependymoma | 1.300 | 1.3e-06 |
| Gaucher disease type 1 | -1.600 | 1.9e-02 |
| group 4 medulloblastoma | 1.500 | 8.5e-04 |
| hereditary spastic paraplegia | -1.019 | 2.6e-03 |
| intraductal papillary-mucinous adenoma (... | 1.200 | 1.9e-02 |
| intraductal papillary-mucinous carcinoma... | 1.100 | 1.3e-02 |
| medulloblastoma, large-cell | 1.200 | 1.2e-04 |
| ovarian cancer | -2.400 | 6.9e-08 |
| spina bifida | -2.179 | 3.8e-02 |
MDLVGVASPEPGTAAAWGPSKCPWAIPQNTISCSLADVMSEQLAKELQLEEEAAVFPEVAVAEGPFITGE 1 - 70 NIDTSSDLMLAQMLQMEYDREYDAQLRREEKKFNGDSKVSISFENYRKVHPYEDSDSSEDEVDWQDTRDD 71 - 140 PYRPAKPVPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPEFQVGDGIGMDLKLSNHVFNALKQHA 141 - 210 YSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSMEDEKEDS 211 - 280 KVIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLARMQRAGIPCPTVV 281 - 350 LLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVW 351 - 420 LIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEADFLAEIEALEK 421 - 490 MNEDHVQKNGRKAASFLKDDGDPPLLYDE 491 - 519 //
