Tbio RHOT2 Mitochondrial Rho GTPase 2

Protein Summary

Description

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity). This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q8IXI1
• A2IDC2
• Q8NF53
• Q96C13
• Q96S17
• Q9BT60
• Q9H7M8
• MIRO-2

Gene Name

• RHOT2

Ensembl ID

• ENST00000315082
• ENSP00000321971
• ENSG00000140983

Symbol

• ARHT2
• C16orf39
• RASL
• ARHT2
• MIRO2
• MIRO-2
• C16orf39

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
interacting protein	0.95
molecular function	0.95
histone modification site profile	0.73
transcription factor	0.66

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Mitochondrial Rho Gtpase 2

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Mitochondrial Rho Gtpase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.82   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.82   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0