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Tbio
RHD
Blood group Rh(D) polypeptide

Protein Summary
Description
May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328664
  • ENSP00000331871
  • ENSG00000187010
  • ENST00000342055
  • ENSP00000339577
  • ENST00000357542
  • ENSP00000350150
  • ENST00000417538
  • ENSP00000396420
  • ENST00000454452
  • ENSP00000413849

Symbol
  • RH
  • Rh4
  • RH30
  • RhII
  • RhPI
  • DIIIc
  • RHCED
  • RHDel
  • RHPII
  • RhDCw
  • CD240D
  • RHXIII
  • RHDVA(TT)
  • RhK562-II
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.81
biological term
0.8
cell type or tissue
0.63
transcription factor perturbation
0.61
cell line
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1117.36   (req: < 5)
Gene RIFs: 135   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1117.36   (req: >= 5)
Gene RIFs: 135   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0