Property Summary

NCBI Gene PubMed Count 14
PubMed Score 6.23
PubTator Score 7.99

Knowledge Summary


No data available


  Differential Expression (10)

Disease log2 FC p
osteosarcoma -3.219 2.0e-06
ependymoma 1.200 2.0e-11
atypical teratoid / rhabdoid tumor 1.500 6.3e-11
glioblastoma 1.400 3.5e-06
medulloblastoma 1.300 4.8e-07
medulloblastoma, large-cell 1.300 1.9e-05
primitive neuroectodermal tumor 1.100 2.5e-03
tuberculosis 1.100 2.3e-06
pilocytic astrocytoma 1.200 9.4e-06
spina bifida -1.190 2.2e-02

Gene RIF (5)

23883433 this study shows that RHBDD1 gene engineering could be used as an effective tool in malignant brain tumor therapy.
23669365 RHBDD1 could inhibit cell apoptosis by activating and upregulating c-Jun and its downstream target, Bcl-3
23534782 Our data show that in vitro RHBDD1 silencing regulates HepG2 cell proliferation and apoptosis.
22624035 RHBDD1 is involved in the regulation of a nonclassical exosomal secretion pathway through the restriction of TSAP6.
18953687 RHBDD1, a serine protease, modulates BIK-mediated apoptotic activity.

AA Sequence

SLWDRGNTRNSPPPYGFHLSPEEMRRQRLHRFDSQ                                       281 - 315

Text Mined References (15)

PMID Year Title
23883433 2014 Lentiviral vector mediated delivery of RHBDD1 shRNA down regulated the proliferation of human glioblastoma cells.
23669365 2013 Rhomboid domain containing 1 inhibits cell apoptosis by upregulating AP-1 activity and its downstream target Bcl-3.
23534782 2013 Lentivirus-mediated silencing of rhomboid domain containing 1 suppresses tumor growth and induces apoptosis in hepatoma HepG2 cells.
22795130 2012 Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.
22624035 2012 Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.
18953687 2008 A novel member of the Rhomboid family, RHBDD1, regulates BIK-mediated apoptosis.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17903307 2007 Framingham Heart Study genome-wide association: results for pulmonary function measures.
16751776 2006 A germline-specific class of small RNAs binds mammalian Piwi proteins.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12838346 2003 Human and mouse proteases: a comparative genomic approach.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.