Tchem | Regulator of G-protein signaling 8 |
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | P-value |
---|---|---|
Astrocytoma, Pilocytic | 3081 | 3.3e-08 |
glioblastoma | 5792 | 9.5e-07 |
atypical teratoid / rhabdoid tumor | 5112 | 7.5e-04 |
diabetes mellitus | 1728 | 1.3e-03 |
adult high grade glioma | 3801 | 1.4e-03 |
medulloblastoma, large-cell | 6241 | 2.3e-03 |
astrocytic glioma | 2597 | 6.9e-03 |
oligodendroglioma | 2850 | 8.1e-03 |
ependymoma | 4679 | 1.0e-02 |
facioscapulohumeral dystrophy | 288 | 1.0e-02 |
group 3 medulloblastoma | 4104 | 3.7e-02 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Spinocerebellar ataxia type 2 | 23 | 3.95 | 2.0 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | -1.900 | 1.4e-03 |
astrocytic glioma | -1.800 | 6.9e-03 |
Astrocytoma, Pilocytic | -2.800 | 3.3e-08 |
atypical teratoid / rhabdoid tumor | -2.200 | 7.5e-04 |
diabetes mellitus | 1.100 | 1.3e-03 |
ependymoma | -1.900 | 1.0e-02 |
facioscapulohumeral dystrophy | 2.300 | 1.0e-02 |
glioblastoma | -2.200 | 9.5e-07 |
group 3 medulloblastoma | -1.600 | 3.7e-02 |
medulloblastoma, large-cell | -2.000 | 2.3e-03 |
oligodendroglioma | -1.800 | 8.1e-03 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |