| Tbio | Regulator of G-protein signaling 8 |
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541). Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| Astrocytoma, Pilocytic | 3006 | 3.3e-08 |
| glioblastoma | 5635 | 9.5e-07 |
| atypical teratoid / rhabdoid tumor | 4971 | 7.5e-04 |
| diabetes mellitus | 1683 | 1.3e-03 |
| adult high grade glioma | 3701 | 1.4e-03 |
| medulloblastoma, large-cell | 6086 | 2.3e-03 |
| astrocytic glioma | 2530 | 6.9e-03 |
| oligodendroglioma | 2768 | 8.1e-03 |
| ependymoma | 4559 | 1.0e-02 |
| facioscapulohumeral dystrophy | 281 | 1.0e-02 |
| group 3 medulloblastoma | 4002 | 3.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Spinocerebellar ataxia type 2 | 23 | 3.95 | 2.0 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.900 | 1.4e-03 |
| astrocytic glioma | -1.800 | 6.9e-03 |
| Astrocytoma, Pilocytic | -2.800 | 3.3e-08 |
| atypical teratoid / rhabdoid tumor | -2.200 | 7.5e-04 |
| diabetes mellitus | 1.100 | 1.3e-03 |
| ependymoma | -1.900 | 1.0e-02 |
| facioscapulohumeral dystrophy | 2.300 | 1.0e-02 |
| glioblastoma | -2.200 | 9.5e-07 |
| group 3 medulloblastoma | -1.600 | 3.7e-02 |
| medulloblastoma, large-cell | -2.000 | 2.3e-03 |
| oligodendroglioma | -1.800 | 8.1e-03 |
