Property Summary

NCBI Gene PubMed Count 114
PubMed Score 257.96
PubTator Score 202.79

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (28)

Disease log2 FC p
malignant mesothelioma -7.600 4.2e-09
astrocytoma -5.500 3.7e-04
ependymoma -5.400 1.0e-03
oligodendroglioma -3.500 2.5e-17
cutaneous lupus erythematosus 1.800 8.1e-03
glioblastoma -4.400 1.4e-04
osteosarcoma 1.991 2.2e-02
medulloblastoma -5.300 4.5e-07
periodontitis 1.400 3.6e-23
atypical teratoid / rhabdoid tumor -4.200 4.9e-05
medulloblastoma, large-cell -4.700 2.2e-03
primitive neuroectodermal tumor -3.500 6.4e-03
non-small cell lung cancer 1.150 4.9e-06
intraductal papillary-mucinous adenoma (... -1.400 3.2e-02
intraductal papillary-mucinous carcinoma... -1.900 1.5e-02
lung cancer 1.300 5.1e-03
Parkinson's disease -1.400 2.7e-02
interstitial cystitis 1.300 4.9e-02
pediatric high grade glioma -3.300 7.3e-04
pilocytic astrocytoma -2.600 2.9e-03
severe Alzheimer's disease -1.711 3.7e-02
lung carcinoma 1.800 3.5e-10
Pick disease -2.100 1.0e-02
Breast cancer 2.200 1.4e-08
ductal carcinoma in situ 1.400 2.1e-02
ulcerative colitis 1.400 3.0e-03
ovarian cancer -4.600 5.2e-14
Down syndrome -1.300 1.2e-02

Protein-protein Interaction (1)

MLP Assay (12)

AID Type Active / Inconclusive / Inactive Description
1872 confirmatory 27 / 0 / 158 Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao.
2295 confirmatory 18 / 0 / 18 Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS4-Galphao for SAR compounds
463111 screening 2824 / 0 / 302855 Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate regulator of G-protein signaling 4 (RGS4)
463165 screening 1365 / 0 / 304314 Primary cell-based high-throughput screening assay for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4)
485274 summary 0 / 0 / 0 Summary of probe development for potentiators of the regulator of G-protein signaling 4 (RGS4)
485289 summary 0 / 0 / 0 Summary of probe development for inhibitors of the regulator of G-protein signaling 4 (RGS4)
492999 screening 1078 / 0 / 584 Validation assay for identification of compounds that inhibit the regulator of G-protein signaling 4 (RGS4)
493000 screening 386 / 0 / 1539 Counter screen for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay
493001 screening 428 / 0 / 1497 Second counter screen for identification of compounds that inhibit regulator of G-protein signaling 4 (RGS4): Non-induced cells with the primary screen assay without carbachol activation
602282 screening 1022 / 0 / 125 Validation assay for identification of compounds that activate the regulator of G-protein signaling 4 (RGS4)
More...

Gene RIF (105)

PMID Text
26640232 All of these results confirmed the critical role of RGS4 in NSCLC progression.
26119705 After alphao dissociates from MOR, RGS4 remains bound to the C-terminal region of MOR
26088132 RGS4 deletion results in a predisposition to atrial fibrillation from enhanced activity in the G-protein pathway, resulting in abnormal calcium release and corresponding electrical events.
25289860 RGS2 and RGS4 are new interacting partners that play key roles in G protein coupling to negatively regulate kappa-OmicronR signaling.
24297163 ectopic expression of R4 subfamily members RGS2, RGS3, RGS4, and RGS5 reduced activated PAR1 wild-type signaling, whereas signaling by the PAR1 AKKAA mutant was minimally affected.
23911251 RGS4 and COMT risk variants are associated with brain structural alterations in patient with schizophrenia.
23733193 Data indicate that Rab5, Rab7 and Rab11 are involved in RGS4 traffics through plasma membrane recycling or endosome.
23630294 dramatic up-regulation of RGS4 expression in the nucleus accumbens of subjects treated with monoamine-directed antidepressants
23332465 genetic association study in Chinese Han population: Data suggest an SNP in RGS4 (rs10759) is associated with increased predisposition to schizophrenia via down-regulation of miroRNA (MIRN124) binding to 3-prime-untranslated region of RGS4 mRNA.
23093381 The results suggest unaltered membrane RGS4 and cytosolic RGS10 proteins levels in schizophrenia and major depression.
22753418 Cys-2 and Cys-12 play markedly different roles in the regulation of RGS4 membrane localization, intracellular trafficking, and G(q) inhibitory function via mechanisms that are unrelated to RGS4 protein stabilization.
22253691 These studies indicate that increased RGS4 expression promotes a phenotypic switch of airway smooth muscle, evoking irreversible airway obstruction in subjects with severe asthma.
22157635 Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia.
21910931 RGS4 gene variations specifically disrupt prefrontal control of saccadic eye movements.
21674833 The researchers found evidence that there were significant differences between the D1S1656 locus in the Maghreb population and other populations.
21209077 Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.
21041608 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20816714 RGS4 and RGS10 proteins are detected in postmortem prefrontal cortex.
20712983 Localization of Sst2 to the projection prevents excess G-protein activation during the pheromone response.
20630860 A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20627871 Observational study of gene-disease association. (HuGE Navigator)
20430014 Observational study of gene-disease association. (HuGE Navigator)
20414142 RGS4 is a potential susceptible gene for bipolar disorder.
20414142 Observational study of gene-disease association. (HuGE Navigator)
19937977 A homogeneous sample of 280 schizophrenia patients and 230 healthy controls of Hungarian, Caucasian descent were genotyped for polymorphisms in schizophrenia candidate genes NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A.
19937977 Observational study of gene-disease association. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19549919 Findings point to the existence of a mechanism for posttranslational regulation of RGS4 function, which may have important implications for the acquisition of a metastatic phenotype by breast cancer cells.
19536175 Observational study of gene-disease association. (HuGE Navigator)
19460752 Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
19416973 role for endogenous RGS4 protein in modulating delta-opioid receptor signaling in SH-SY5Y cells
19367581 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19324084 RGS4 plays a key role in G protein coupling selectivity and signaling of the mu- and delta-opioid receptors.
19282471 RGS4 polymorphisms are associated with variations in cognitive functions and contribute a small but statistically significant proportion of variance in a family-based sample.
19282471 Observational study of gene-disease association. (HuGE Navigator)
19201815 Prostaglandin E(2) can induce MUC5AC overproduction via the EP(4) receptor and that RGS4 may have suppressive effects in controlling MUC5AC overexpression in the airway.
19059885 Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway.
19041089 results suggest the possibility that alterations in the expression of RGS4-3 contribute to the development of SCZ.
18834502 Observational study of gene-disease association. (HuGE Navigator)
18804346 We found evidence of a joint effect between IL3 (rs31400) and DTNBP1
18804346 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18622782 Altered RGS4 expression is not universally present throughout the cortex of people with schizophrenia.
18584117 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
18583979 Meta-analysis of gene-disease association. (HuGE Navigator)
18470533 Data show that the expression of RGS4 decreases in the prefrontal cortex of postmortem brain samples spanning half a century of human aging (18-67 years).
18443239 Transgenic overexpression of cardiac myocyte-specific RGS4 attenuates overexpression of hypertrophy-related genes in guanylyl cyclase A-knockout mice.
18434012 RGS4 polymorphism was not associated with treatment response to electroconvulsive therapy in major depressive disorder
18434012 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
18262772 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18204343 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18204343 RGS4 variances influence clinical manifestations of schizophrenia
18198266 Observational study of gene-disease association. (HuGE Navigator)
18031991 The isolation and characterization of a novel human RGS4 mutant which displays enhanced or gain-of-function (GOF) activity, is described.
17722013 the association of regulator of G-protein signalling 4 protein polymorphisms with the phenotypic subgroups of schizophrenia.
17722013 Observational study of gene-disease association. (HuGE Navigator)
17707117 Full length cloning and expression analysis of splice variants of RGS4 were performed.
17707117 Multiple splice variant forms of RGS4 and Rgs4 are expressed in human and mouse brain and show differential expression across brain compartments.
17588543 Observational study of gene-environment interaction and pharmacogenomic / toxicogenomic. (HuGE Navigator)
17588543 RGS4 genotypes predicted both the severity of baseline symptoms and relative responsiveness to antipsychotic treatment in patient with schizophrenia.
17515439 study identified all common RGS4 polymorphisms & evaluated patterns of linkage disequilibrium in relation to schizophrenia; 2 haplotypes reported to confer liability to SZ had significant promoter activity suggesting functional role for both haplotypes
17410640 Observational study of gene-disease association. (HuGE Navigator)
17410640 In RGS4, the G-allele of the previously reported SNP RGS4-1 (single and as part of haplotypes with SNP RGS4-18) was associated with non-deficit schizophrenia but not with deficit schizophrenia.
17408693 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17301167 Observational study of gene-disease association. (HuGE Navigator)
17301167 RGS4 single nucleotide polymorphism impacts frontal lobe blood oxygenation level-dependent response and network coupling during working memory and results in reductions in gray, white matter structural volume in individuals carrying the A allele.
17220356 examined function, receptor specificity, and expression of R4 subfamily RGS proteins, RGS2, -3, -4, -5, and -8 via missense mutations introduced
17106420 Observational study of gene-disease association. (HuGE Navigator)
17092693 Observational study of gene-disease association. (HuGE Navigator)
17055463 Observational study of gene-disease association. (HuGE Navigator)
17006672 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
17006672 SNPs in RGS4, G72, GRM3, and DISC1 showed evidence for significant statistical epistasis with COMT.
16905560 RGS4 mRNA was inversely correlated with COMT enzyme activity in the dorsolateral prefrontal cortex
16904822 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
16904822 Genetic polymorphisms within RGS4 are unlikely to confer an increased susceptibility to the etiology of schizophrenia.
16860780 RGS4 is an example of a molecule that may underlie increased vulnerability through either genetic or non-genetic mechanisms, which we suggest may be typical of other genes in a complex, polygenic disorder such as schizophrenia.
16791139 Meta-analysis of gene-disease association. (HuGE Navigator)
16791139 this meta-analysis did not find statistically significant evidence for association between RGS4 and PRODH and schizophrenia on the basis of either allelic or genotypic analysis.
16631129 Meta-analysis of gene-disease association. (HuGE Navigator)
16604300 Observational study of gene-disease association. (HuGE Navigator)
16526029 Observational study of gene-disease association. (HuGE Navigator)
16526029 Results fail to support the RGS4 as a candidate gene for schizophrenia when evaluated with three SNP markers from promoter region and intron 1.
16508931 Observational study of gene-disease association. (HuGE Navigator)
16508931 Finding weakens the evidence that mutations or variation in the RGS4 gene have an effect on schizophrenia susceptibility.
16380905 Observational study of gene-disease association. (HuGE Navigator)
16246308 These results provide the first demonstration of a Ca(2+)-dependent interaction between RGS4 and CaM in vivo and show that association in lipid rafts of the plasma membrane might be involved in this physiological regulation of RGS proteins.
16176390 Observational study of gene-disease association. (HuGE Navigator)
16176390 Data do not directly replicate previous associations of RGS4, but association with SNP 7 in the Scottish population provides some support for a role in schizophrenia susceptibility.
16082709 Observational study of gene-disease association. (HuGE Navigator)
16082709 No association is identified between RGS4 single nucleotide polymorphism (SNP) markers, genotypes, or haplotypes and schizophrenia
15660667 Observational study of gene-disease association. (HuGE Navigator)
15660667 In schizophrenia, significant case-control differences were not observed, though the TDT suggested transmission distortion. For bipolar disorder, an omnibus test suggested differences in the overall distribution of haplotypes bearing all four SNPs.
15383626 Although gross indices of signaling were unaffected by RGS4, it slowed the rate of increase in Ins(1,4,5)P3 levels.
15381923 Observational study of gene-disease association. (HuGE Navigator)
15381923 RGS4 polymorphisms are associated with alterations in dorsolateral prefrontal cortex (area 9) volumes among schizophrenic patients.
15369705 RGS4 and beta-tubulin modulate Galpha-GDP and Galpha-GTP states thus modulating MT1 melatonin receptor function.
15274033 Results could be interpreted as supporting evidence for the association between RGS4 and schizophrenia.
15182322 RGS4 mRNA distribution in human postmortem tissue from normal persons was very dense in most cortical layers examined, with lower density in the basal ganglia and thalamus.
14755443 Observational study of gene-disease association. (HuGE Navigator)
14732600 Observational study of gene-disease association. (HuGE Navigator)
14732600 The data of this research give modest support for the hypothesis that the regulator of G-protein signaling 4 is a susceptibility gene for schizophrenia.
12642592 results suggest that palmitoylation of a Cys residue in the regulator of G protein signaling(RGS) box is critical for RGS16 and RGS4 GAPase activating protein activity and their ability to regulate G protein signaling in mammalian cells
12436019 A significant decrease in the transcript encoding regulator of G-protein signaling 4 (RGS4) in the prefrontal cortex of patients with schizophrenia.
12422374 cytosolic and membrane levels of RGS4 may contribute to the regional differences in the coupling of muscarinic M1 receptors in Alzheimer's disease
12023979 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MCKGLAGLPASCLRSAKDMKHRLGFLLQKSDSCEHNSSHNKKDKVVICQRVSQEEVKKWAESLENLISHE      1 - 70
CGLAAFKAFLKSEYSEENIDFWISCEEYKKIKSPSKLSPKAKKIYNEFISVQATKEVNLDSCTREETSRN     71 - 140
MLEPTITCFDEAQKKIFNLMEKDSYRRFLKSRFYLDLVNPSSCGAEKQKGAKSSADCASLVPQCA         141 - 205
//

Text Mined References (114)

PMID Year Title
26640232 2016 Regulator of G-protein signaling 4: A novel tumor suppressor with prognostic significance in non-small cell lung cancer.
26119705 2015 Mu opioid receptor activation enhances regulator of G protein signaling 4 association with the mu opioid receptor/G protein complex in a GTP-dependent manner.
26088132 2015 Absence of the Regulator of G-protein Signaling, RGS4, Predisposes to Atrial Fibrillation and Is Associated with Abnormal Calcium Handling.
25289860 2015 RGS2 and RGS4 proteins: New modulators of the ?-opioid receptor signaling.
24297163 2014 Regulation of protease-activated receptor 1 signaling by the adaptor protein complex 2 and R4 subfamily of regulator of G protein signaling proteins.
24009623 2013 Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
23911251 2013 RGS4 and COMT risk variants are associated with brain structural alterations.
23733193 2013 Rab family proteins regulate the endosomal trafficking and function of RGS4.
23630294 2013 Regulator of G protein signaling 4 [corrected] is a crucial modulator of antidepressant drug action in depression and neuropathic pain models.
23332465 2013 Polymorphisms in microRNA target sites influence susceptibility to schizophrenia by altering the binding of miRNAs to their targets.
23093381 2013 Brain RGS4 and RGS10 protein expression in schizophrenia and depression. Effect of drug treatment.
22753418 2012 Amino-terminal cysteine residues differentially influence RGS4 protein plasma membrane targeting, intracellular trafficking, and function.
22253691 2012 An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma.
22157635 2012 Lack of association between the regulator of G-protein signaling 4 (RGS4) rs951436 polymorphism and schizophrenia.
21910931 2012 Schizophrenia-related RGS4 gene variations specifically disrupt prefrontal control of saccadic eye movements.
21674833 2011 Genetic variation at 5 new autosomal short tandem repeat markers (D10S1248, D22S1045, D2S441, D1S1656, D12S391) in a population-based sample from Maghreb region.
21209077 2011 Opioid-induced down-regulation of RGS4: role of ubiquitination and implications for receptor cross-talk.
21041608 2011 Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.
20816714 2010 Characterization of regulators of G-protein signaling RGS4 and RGS10 proteins in the postmortem human brain.
20712983 2010 The effects of replacing Sst2 with the heterologous RGS4 on polarization and mating in yeast.
20630860 2010 A novel mechanism involving coordinated regulation of nuclear levels and acetylation of NF-YA and Bcl6 activates RGS4 transcription.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20627871 2010 Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
20430014 2010 Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics.
20414142 2010 Association study between RGS4 and bipolar disorder in the Chinese Han population.
19937977 2010 Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19549919 2009 Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4.
19536175 2009 Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.
19416973 2009 Differential modulation of mu- and delta-opioid receptor agonists by endogenous RGS4 protein in SH-SY5Y cells.
19367581 2010 Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
19324084 2009 Regulator of G protein signaling 4 confers selectivity to specific G proteins to modulate mu- and delta-opioid receptor signaling.
19282471 2010 RGS4 polymorphisms associated with variability of cognitive performance in a family-based schizophrenia sample.
19201815 2009 Suppression of prostaglandin E2-induced MUC5AC overproduction by RGS4 in the airway.
19059885 2009 Regulator of G-protein signaling 4 suppresses LPS-induced MUC5AC overproduction in the airway.
19041089 2009 Expression of RGS4 splice variants in dorsolateral prefrontal cortex of schizophrenic and bipolar disorder patients.
18834502 2008 Association of RGS4 variants with schizotypy and cognitive endophenotypes at the population level.
18804346 2008 Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.
18622782 2008 Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia.
18584117 2008 Two-stage designs to identify the effects of SNP combinations on complex diseases.
18583979 2008 Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
18470533 2008 Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex.
18443239 2008 Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart.
18434012 2008 RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder.
18262772 2008 Association of RGS2 and RGS5 variants with schizophrenia symptom severity.
18204343 2008 RGS4 polymorphisms predict clinical manifestations and responses to risperidone treatment in patients with schizophrenia.
18198266 2008 No significant association of 14 candidate genes with schizophrenia in a large European ancestry sample: implications for psychiatric genetics.
18031991 2008 Isolation and characterization of a novel human RGS mutant displaying gain-of-function activity.
17722013 2008 An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population.
17707117 2007 Full length cloning and expression analysis of splice variants of regulator of G-protein signaling RGS4 in human and murine brain.
17588543 2008 Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia.
17515439 2008 Linkage disequilibrium patterns and functional analysis of RGS4 polymorphisms in relation to schizophrenia.
17410640 2007 The PIP5K2A and RGS4 genes are differentially associated with deficit and non-deficit schizophrenia.
17408693 2008 Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction.
17301167 2007 Allelic variation in RGS4 impacts functional and structural connectivity in the human brain.
17220356 2007 N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells.
17106420 2006 Bipolar 1 disorder is not associated with the RGS4, PRODH, COMT and GRK3 genes.
17092693 2007 RGS4 is not a susceptibility gene for schizophrenia in Japanese: association study in a large case-control population.
17055463 2007 Significant support for DAO as a schizophrenia susceptibility locus: examination of five genes putatively associated with schizophrenia.
17006672 2007 Evidence for statistical epistasis between catechol-O-methyltransferase (COMT) and polymorphisms in RGS4, G72 (DAOA), GRM3, and DISC1: influence on risk of schizophrenia.
16905560 2006 RGS4 mRNA expression in postmortem human cortex is associated with COMT Val158Met genotype and COMT enzyme activity.
16904822 2006 RGS4 polymorphisms and risk of schizophrenia: an association study in Han Chinese plus meta-analysis.
16860780 2006 Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4).
16791139 2006 Association study of the G-protein signaling 4 (RGS4) and proline dehydrogenase (PRODH) genes with schizophrenia: a meta-analysis.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16631129 2006 Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples.
16604300 2006 RGS4 genotype is not associated with antipsychotic medication response in schizophrenia.
16526029 2006 Evaluation of RGS4 as a candidate gene for schizophrenia.
16508931 2006 Failure to confirm genetic association between schizophrenia and markers on chromosome 1q23.3 in the region of the gene encoding the regulator of G-protein signaling 4 protein (RGS4).
16380905 2005 Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
16246308 2005 In vivo interaction between RGS4 and calmodulin visualized with FRET techniques: possible involvement of lipid raft.
16176390 2005 Association analysis of the RGS4 gene in Han Chinese and Scottish populations with schizophrenia.
16082709 2005 Failure to confirm association between RGS4 haplotypes and schizophrenia in Caucasians.
15660667 2005 Association and linkage analysis of RGS4 polymorphisms with schizophrenia and bipolar disorder in Brazil.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15383626 2004 Single-cell imaging of intracellular Ca2+ and phospholipase C activity reveals that RGS 2, 3, and 4 differentially regulate signaling via the Galphaq/11-linked muscarinic M3 receptor.
15381923 2005 Genetic polymorphisms of the RGS4 and dorsolateral prefrontal cortex morphometry among first episode schizophrenia patients.
15369705 2004 Knock-down of RGS4 and beta tubulin in CHO cells expressing the human MT1 melatonin receptor prevents melatonin-induced receptor desensitization.
15274033 2004 Regulator of G-protein signaling 4 (RGS4) gene is associated with schizophrenia in Irish high density families.
15182322 2004 Regional expression of RGS4 mRNA in human brain.
14755443 2004 Confirming RGS4 as a susceptibility gene for schizophrenia.
14732600 2004 Support for RGS4 as a susceptibility gene for schizophrenia.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12920194 2003 Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions.
12840049 2003 Identification of novel ErbB3-interacting factors using the split-ubiquitin membrane yeast two-hybrid system.
12642592 2003 Palmitoylation regulates regulator of G-protein signaling (RGS) 16 function. II. Palmitoylation of a cysteine residue in the RGS box is critical for RGS16 GTPase accelerating activity and regulation of Gi-coupled signalling.
12564955 2003 The aorta and heart differentially express RGS (regulators of G-protein signalling) proteins that selectively regulate sphingosine 1-phosphate, angiotensin II and endothelin-1 signalling.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12436019 2002 Current progress in schizophrenia research: application of emerging "gene chip" technologies in search of genes.
12422374 2003 Differences in regional and subcellular localization of G(q/11) and RGS4 protein levels in Alzheimer's disease: correlation with muscarinic M1 receptor binding parameters.
12023979 2002 Association and linkage analyses of RGS4 polymorphisms in schizophrenia.
11904384 2002 PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel.
11507164 2001 Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel.
11428836 2001 Expression of RGS3, RGS4 and Gi alpha 2 in acutely failing donor hearts and end-stage heart failure.
11297424 2001 RGS4 inhibits platelet-activating factor receptor phosphorylation and cellular responses.
11148035 2001 Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1.
10982407 2000 RGS4 and RGS2 bind coatomer and inhibit COPI association with Golgi membranes and intracellular transport.
10869340 2000 Novel alternative splicing and nuclear localization of human RGS12 gene products.
10791963 2000 Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and RGS domain sequences as intracellular targeting motifs.
10784452 2000 Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22.
10767329 2000 Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22.
10747990 2000 Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity.
10685342 1999 1H, 15N, 13C, and 13CO assignments and secondary structure determination of RGS4.
10608901 1999 Palmitoylation of a conserved cysteine in the regulator of G protein signaling (RGS) domain modulates the GTPase-activating activity of RGS4 and RGS10.
10387017 1999 Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue.
9754621 1998 A genome-wide search for schizophrenia susceptibility genes.
9748280 1998 RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily.
9674973 1998 Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium.
9660808 1998 Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane.
9576926 1998 Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.
9405622 1997 RGS2/G0S8 is a selective inhibitor of Gqalpha function.
8756726 1996 GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits.
8602223 1996 Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family.