Property Summary

NCBI Gene PubMed Count 17
PubMed Score 36.04
PubTator Score 9.32

Knowledge Summary


No data available


  Differential Expression (17)

Disease log2 FC p
gastric cancer 1.300 1.7e-02
hepatocellular carcinoma 1.700 2.3e-05
pancreatic cancer 1.800 1.7e-03
osteosarcoma -3.228 3.7e-03
chronic lymphosyte leukemia -1.100 8.7e-07
non-small cell lung cancer -1.728 1.3e-18
intraductal papillary-mucinous carcinoma... -1.200 1.5e-02
interstitial cystitis 1.800 3.2e-05
pediatric high grade glioma 1.100 9.4e-03
pilocytic astrocytoma 1.900 8.3e-07
pancreatic carcinoma 1.800 1.7e-03
lung adenocarcinoma -1.800 1.8e-10
lung carcinoma -1.300 6.3e-13
spina bifida -1.062 4.9e-02
mucosa-associated lymphoid tissue lympho... 1.105 1.8e-02
ulcerative colitis 1.700 4.0e-04
ovarian cancer -2.100 2.4e-09


Accession Q9NS28 B2RD23 RGS18
Symbols RGS13


PANTHER Protein Class (2)


2DLV   2JM5   2OWI  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (7)

22234696 These findings indicate cross-talk between platelet activation and inhibition pathways at the level of RGS18 and Gq.
22210881 Data show that that SPL/RGS/SHP1 complexes are present in resting platelets where constitutive phosphorylation of SPL(Y398) creates an atypical binding site for SHP-1.
20627871 Observational study of gene-disease association. (HuGE Navigator)
20468064 Observational study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
16484797 gene mapped to chromosome 1.
11955952 molecular cloning and characterization of RGS18 as a regulator of G protein signalling in human platelets

AA Sequence

NLRRRSRSFTCNEFQDVQSDVAIWL                                                 211 - 235

Text Mined References (18)

PMID Year Title
22234696 2012 Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets.
22210881 2012 A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.
20627871 2010 Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
20468064 2010 Association study of 182 candidate genes in anorexia nervosa.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16484797 2006 Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14992813 2004 Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14645010 2004 Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins.
12665801 2003 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11955952 2002 Cloning and characterization of a novel regulator of G protein signalling in human platelets.
11829488 2002 Evolution of the regulators of G-protein signaling multigene family in mouse and human.
11563974 2001 RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes.
11342430 2001 A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes.
11042171 2001 Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells.