Protein Summary
Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling.
- ENST00000295049
- ENSP00000295049
- ENSG00000162944
- C2orf11
- C2orf11
- Raftlin-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell type or tissue | 0.89 | ||
transcription factor perturbation | 0.68 | ||
tissue sample | 0.62 | ||
cell line | 0.57 | ||
microRNA | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.22 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 111 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.22 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 111 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0