Property Summary

NCBI Gene PubMed Count 15
PubMed Score 5.13
PubTator Score 6.70

Knowledge Summary


No data available


  Differential Expression (27)

Disease log2 FC p
Waldenstrons macroglobulinemia -1.824 3.4e-02
malignant mesothelioma -1.500 3.2e-07
chronic lymphosyte leukemia -1.500 1.9e-06
medulloblastoma -1.900 1.1e-04
atypical teratoid / rhabdoid tumor -1.100 4.7e-02
medulloblastoma, large-cell -2.400 3.9e-05
adrenocortical carcinoma -1.177 1.9e-02
primary pancreatic ductal adenocarcinoma 2.697 8.5e-05
non-small cell lung cancer -1.406 4.9e-17
intraductal papillary-mucinous adenoma (... -2.000 6.5e-03
intraductal papillary-mucinous carcinoma... -2.200 6.8e-03
lung cancer -1.400 5.1e-05
fibroadenoma -1.700 2.1e-02
interstitial cystitis 1.600 7.3e-04
cystic fibrosis 1.100 3.8e-04
primary Sjogren syndrome 1.900 1.4e-04
sarcoidosis -1.100 1.5e-05
subependymal giant cell astrocytoma 1.739 2.4e-02
lung adenocarcinoma -1.100 1.6e-05
lung carcinoma -1.300 3.3e-19
Breast cancer 1.700 1.6e-07
gastric carcinoma 1.800 1.3e-02
ductal carcinoma in situ -1.100 2.4e-02
invasive ductal carcinoma -1.500 9.2e-03
ulcerative colitis 2.900 9.1e-06
ovarian cancer -2.500 8.8e-06
pancreatic cancer 2.600 3.1e-04

 GO Function (1)

Gene RIF (6)

23645746 Mitogen-inducible Gene-2 expression is reduced in breast cancer.
22222511 combination of ATOH7 and RFTN1 SNPs increased risk to POAG, indicating their diversified effects in the complex genetics of glaucoma.
21266579 Raftlin cooperates with the uptake receptor to mediate cell entry of poly(I:C), which is critical for activation of TLR3.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
19834535 Observational study of gene-disease association. (HuGE Navigator)
12805216 These data suggest that Raftlin plays a pivotal role in the formation and/or maintenance of lipid rafts, therefore regulating B-cell antigen receptor-mediated signaling.

AA Sequence

ARDGDAEEVRELGTVEEN                                                        561 - 578

Text Mined References (20)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23645746 2013 Mitogen-inducible Gene-2 (MIG2) and migfilin expression is reduced in samples of human breast cancer.
22222511 2012 Interactive effects of ATOH7 and RFTN1 in association with adult-onset primary open-angle glaucoma.
21955986 2011 Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21266579 2011 Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
20395239 2010 Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20213681 2010 Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system.
19834535 2009 Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19553259 2009 Common body mass index-associated variants confer risk of extreme obesity.
17081983 2006 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12805216 2003 The B cell-specific major raft protein, Raftlin, is necessary for the integrity of lipid raft and BCR signal transduction.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
7788527 1995 Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.