You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
REPIN1
Replication initiator 1

Protein Summary
Description
Sequence-specific double-stranded DNA-binding protein required for initiation of chromosomal DNA replication. Binds on 5'-ATT-3' reiterated sequences downstream of the origin of bidirectional replication (OBR) and a second, homologous ATT sequence of opposite orientation situated within the OBR zone. Facilitates DNA bending.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397281
  • ENSP00000380451
  • ENSG00000214022
  • ENST00000425389
  • ENSP00000388287
  • ENST00000444957
  • ENSP00000407714
  • ENST00000489432
  • ENSP00000417291

Symbol
  • RIP60
  • ZNF464
  • AP4
  • RIP60
  • ZNF464
  • Zfp464
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.8
disease perturbation
0.79
transcription factor binding site profile
0.78
transcription factor perturbation
0.68
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.63   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.63   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0