Tdark REC114 Meiotic recombination protein REC114

Protein Summary

Description

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. The protein encoded by this gene is orthologous to the mouse meiotic recombination protein REC114, which is involved in DNA double-strand break formation during meiosis. The encoded protein is conserved in most eukaryotes and was first discovered and characterized in yeast. [provided by RefSeq, Feb 2017]

Uniprot Accession IDs

• Q7Z4M0

Gene Name

• REC114

Ensembl ID

• ENST00000331090
• ENSP00000328423
• ENSG00000183324

Symbol

• C15orf60
• CT147
• C15orf60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.72
disease	0.64
phenotype	0.59
gene perturbation	0.53
PubMedID	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.79   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 1   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.79   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 1   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0